Title: Aceclofenac
CAS Registry Number: 89796-99-6
CAS Name: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester
Additional Names: 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid; glycolic acid [o-(2,6-dichloroanilino)phenyl]acetate ester
Manufacturers' Codes: PR-82/3
Trademarks: Airtal (Prodes); Falcol (Bayer); Gerbin (Sanofi Winthrop); Preservex (BMS)
Molecular Formula: C16H13Cl2NO4
Molecular Weight: 354.18
Percent Composition: C 54.26%, H 3.70%, Cl 20.02%, N 3.95%, O 18.07%
Literature References: Prepn: A. V. Casas, ES 8404783; idem, US 4548952 (1984, 1985 both to Prodes). Gastrointestinal tolerance in rats in comparison with diclofenac, q.v.: V. Rimbau et al., Farmaco Ed. Prat. 43, 19 (1988). Clinical trial in comparison with acetaminophen, q.v., in episiotomal pain: A. Yscla, Drugs Exp. Clin. Res. 14, 491 (1988). Clinical evaluation in rheumatoid arthritis: R. Ballesteros et al., Clin. Trials J. 27, 12 (1990).
Properties: White crystals from cyclohexane, mp 149-150°. uv max (ethanol): 275 nm (log e 4.14).
Melting point: mp 149-150°
Absorption maximum: uv max (ethanol): 275 nm (log e 4.14)
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.
Acedapsone Acediasulfone Acefylline Aceglatone Aceglutamide

Systematic (IUPAC) name
2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid
Clinical data
AHFS/ International Drug Names
Legal status POM (UK)
Routes oral, topical
CAS number 89796-99-6 N
ATC code M01AB16 M02AA25
PubChem CID 71771
ChemSpider 64809 YesY
KEGG D01545 YesY
Chemical data
Formula C16H13Cl2NO4 
Mol. mass 354.18472 g/mol
 N (what is this?)  (verify)

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID). Aceclofenac is marketed by Intas Pharmaceuticals, Ltd., under the brand name Hifenac in various forms. Aceclofenac is marketed by Kaptab Pharmaceuticals under the brand name Cincofen.Aceclofenac is marketed by fast growing pharmaceutical companies in India Philix Pharmaceuticals under the brand name ACEPHIL. Aceclofenac is also marketed by Saharsh Biologicals as Nacsiv. In Pakistan it is marketed as Acenac . In Bangladesh it is marketed as TERNILLA by Healthcare Pharmaceuticals Ltd. Rephco Pharmaceuticals Limited also markets aceclofenac under the brand name "RAPIDOR". It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The dose is 100 mg twice daily.

It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children.

Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac.