Acefylline

Title: Acefylline
CAS Registry Number: 652-37-9
CAS Name: 1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetic acid
Additional Names: carboxymethyltheophylline; 7-theophyllineacetic acid
Molecular Formula: C9H10N4O4
Molecular Weight: 238.20
Percent Composition: C 45.38%, H 4.23%, N 23.52%, O 26.87%
Literature References: Prepn: DE 352980 (1922 to E. Merck); Frdl. 14, 1320; S. M. Ride et al., Pharmazie 32, 672 (1977). Prepn of salts: J. Baisse, Bull. Soc. Chim. Fr. 1949, 769; M. Milletti, F. Virgili, Chimica 6, 394 (1951), C.A. 46, 8615h (1952). GC determn in urine: J. Zuidema, H. Hilbers, J. Chromatogr. 182, 445 (1980). HPLC determn in serum and pharmacokinetics: S. Sved et al., Biopharm. Drug Dispos. 2, 177 (1981).
Properties: Crystals from water, mp 271°.
Melting point: mp 271°
Derivative Type: Sodium salt
CAS Registry Number: 837-27-4
Molecular Formula: C9H9N4NaO4
Molecular Weight: 260.18
Percent Composition: C 41.55%, H 3.49%, N 21.53%, Na 8.84%, O 24.60%
Properties: Silky needles, mp >300°.
Melting point: mp >300°
Derivative Type: Compd with piperazine
Additional Names: Acefylline piperazine; acepifylline
Trademarks: Dynaphylline (Welcker-Lyster); Etaphylline (Delalande); Etafillina (Delalande)
Properties: Undefined mixture of the 1:1 and 2:1 salts; contains 75-78% theophylline acetic acid and 22-25% anhydrous piperazine.
Therap-Cat: Bronchodilator.
Keywords: Bronchodilator; Xanthine Derivatives.
Aceglatone Aceglutamide Acemannan Acemetacin Acenaphthene

Acefylline
Acefylline.png
Systematic (IUPAC) name
2-(1,3-dimethyl-2,6-dioxo-purin-7-yl)acetic acid
Clinical data
Legal status  ?
Identifiers
CAS number 652-37-9 N
ATC code R03DA09 (acefylline piperazine)
PubChem CID 69550
ChemSpider 62754 YesY
UNII M494UE2YEP YesY
ChEMBL CHEMBL70246 YesY
Chemical data
Formula C9H10N4O4 
Mol. mass 238.20 g/mol
 N (what is this?)  (verify)

Acefylline, also known as acetyloxytheophylline, is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation etanautine to help offset its stimulant effects.[1]

Theophyllines are classified in this group. Other respiratory stimulants are classified in R07AB - Respiratory stimulants.

Corticosteroids for systemic use, see H02.

Sympathomimetics for systemic treatment of rhinitis, see R01BA.

This group comprises mainly the xanthines. The DDDs for these substances are based on treatment of obstructive lung diseases.[2]

A number of preparations containing e.g. theophylline are classified in this group even if they do not have asthma as an indication.

Combinations of xanthines and other agents (except adrenergics, see R03DB - Xanthines and adrenergics) are classified at separate 5th levels using the corresponding 50-series (e.g. mucolytics).[3]