Aceperone

Title: Aceperone
CAS Registry Number: 807-31-8
CAS Name: N-[[1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-phenyl-4-piperidinyl]methyl]acetamide
Additional Names: N-[[1-[3-(p-fluorobenzoyl)propyl]-4-phenyl-4-piperidyl]methyl]acetamide; 1-(p-fluorophenyl)-4-(4-phenyl-4-acetamidomethylpiperidino)-1-butanone; 1-[g-(4-fluorobenzoyl)propyl]-4-acetamidomethyl-4-phenylpiperidine; N-[1-[3-(p-fluorobenzoyl)propyl]-4-phenylpiperidin-4-ylmethyl]acetamide; 4¢-fluoro-4-(4-acetamidomethyl-4-phenylpiperido)butyrophenone; acetabutone; acetobuton
Manufacturers' Codes: R-3248
Molecular Formula: C24H29FN2O2
Molecular Weight: 396.50
Percent Composition: C 72.70%, H 7.37%, F 4.79%, N 7.07%, O 8.07%
Literature References: Prepd by reacting g-chloro-4-fluorobutyrophenone with 4-acetamidomethyl-4-phenylpiperidine: P. A. J. Janssen, BE 606849 (1961), corresp to US 3083205 (1961, 1963 both to Janssen). Crystal structure: N. Van Opdenbosch et al., Acta Crystallogr. 33B, 171 (1977).
Properties: Crystals, mp 97-100°.
Melting point: mp 97-100°
Acephate Acepromazine Acequinocyl Acerin Acerola

Aceperone
Aceperone.svg
Systematic (IUPAC) name
N-({1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-phenyl-4-piperidinyl}methyl)acetamide
Clinical data
Legal status  ?
Identifiers
CAS number 807-31-8
ATC code None
PubChem CID 13122
ChemSpider 12570
UNII S69KXZ59AB
Synonyms Acetabuton; R 3248
Chemical data
Formula C24H29FN2O2 
Mol. mass 396.498 g/mol
Physical data
Melt. point 97–100 °C (207–212 °F) [1]

Aceperone is a neuroleptic drug of the butyrophenone class. It is an α-noradrenergic blocking drug developed by Janssen Pharmaceutica in the 1960s.[1]

Because of its learning impairment effects in animals, aceperone has been used as a tool in the study of the biochemical basis of learning.[2][3][4]