Acetaminosalol

Title: Acetaminosalol
CAS Registry Number: 118-57-0
CAS Name: 2-Hydroxybenzoic acid 4-(acetylamino)phenyl ester
Additional Names: p-acetamidophenyl salicylate; acetylaminophenyl salicylate; acetyl-p-aminosalol; p-acetylaminophenol salicylic acid ester; phenetsal
Trademarks: Salophen (Bayer); Phenosal
Molecular Formula: C15H13NO4
Molecular Weight: 271.27
Percent Composition: C 66.41%, H 4.83%, N 5.16%, O 23.59%
Literature References: Prepn: Brewster, J. Am. Chem. Soc. 40, 1136 (1918).
Properties: Crystals from hot ethanol, mp 187°. Practically insol in petr ether, cold water, more sol in warm water. Sol in alcohol, ether, benzene. Incompatible with alkalies and alkaline solns which dissolve it with decompn. The alkaline soln gradually becomes blue when boiled, the blue color being discharged upon continued boiling and again produced upon cooling and exposure to air.
Melting point: mp 187°
Therap-Cat: Analgesic; antipyretic; anti-inflammatory.
Therap-Cat-Vet: Analgesic; antipyretic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic.
Acetanilide Acetarsone Acetazolamide Acetiamine Acetic Acid Glacial

Acetaminosalol
Kekulé, skeletal formula of acetaminosalol
Identifiers
CAS number 118-57-0 N
PubChem 1984
ChemSpider 1907 YesY
EC number 204-261-3
MeSH Salophen
ChEBI CHEBI:250620 N
ChEMBL CHEMBL92590 YesY
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C15H13NO4
Molar mass 271.27 g mol−1
Density 1.327 g cm-3
log P 2.562
Acidity (pKa) 7.874
Basicity (pKb) 6.123
Hazards
Flash point 241.9 °C; 467.4 °F; 515.0 K
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Acetaminosalol is an organic compound with the chemical formula C15H13NO4.

It is an esterfication product of salicylic acid and paracetamol. It was marketed by Bayer under the brand name Salophen as an analgesic in the late 19th and early 20th centuries.