Aclatonium Napadisilate

Title: Aclatonium Napadisilate
CAS Registry Number: 55077-30-0
CAS Name: 2-[2-(Acetyloxy)-1-oxopropoxy]-N,N,N-trimethylethanaminium 1,5-naphthalenedisulfonate (2:1)
Additional Names: 1,5-naphthalenedisulfonic acid bis [2-[2-(acetyloxy)-1-oxopropoxy]-N,N,N-trimethylethanaminium]ion (2-); acetyllactoylcholine 1,5-naphthalenedisulfonate; choline 1,5-naphthalenedisulfonate (2:1), dilactate, diacetate
Manufacturers' Codes: TM-723
Trademarks: Abovis (Toyama)
Molecular Formula: C30H46N2O14S2
Molecular Weight: 722.82
Percent Composition: C 49.85%, H 6.41%, N 3.88%, O 30.99%, S 8.87%
Literature References: Spasmolytic agent related structurally to acetylcholine chloride, q.v. Prepn: K. Miura et al., DE 2425983; eidem, US 3903137 (1973, 1975 both to Toyama). Synthesis and smooth muscle activity: eidem, Yakugaku Zasshi 99, 1245 (1979), C.A. 92, 146197r (1980). Toxicity study: A. Takai et al., Oyo Yakuri 19, 93 (1980), C.A. 93, 613367 (1980). Series of articles on metabolism, pharmacology, toxicity studies: Oyo Yakuri 18, 695-942 (1979), C.A. 92, 191015r, 191281z, 191282a, 208995k-7n (1980).
Properties: Crystals, mp 189-191°. LD50 in mice: 15 g/kg orally, 826 mg/kg s.c. (Miura); in dogs: >10 g/kg orally (Takai).
Melting point: mp 189-191°
Toxicity data: LD50 in mice: 15 g/kg orally, 826 mg/kg s.c. (Miura); in dogs: >10 g/kg orally (Takai)
Therap-Cat: Cholinergic.
Keywords: Cholinergic.
Aconine Aconite Aconitic Acid Aconitine Aconitine, Amorphous