Title: Actinomycin F1
CAS Registry Number: 1402-44-4
Additional Names: Actinomycin KS4; KS4
Literature References: Antineoplastic antibiotic produced by cultures of actinomycin C-elaborating strains of Streptomyces, such as Streptomyces BOP 476 (NRRL 2580) and Streptomyces chrysomallus (NRRL 2250). Considered to be a derivative of actinomycin C2; amino acid analysis indicates that the prolines present in actinomycin C2 are substituted by sarcosine in actinomycin F1. Production by controlled biosynthesis: Schmidt-Kastner, Naturwissenschaften 43, 131 (1956); idem, Ann. N.Y. Acad. Sci. 89, 299 (1960); Schmidt-Kastner, Hackmann, US 3219544 (1965 to Bayer).