Title: Adiponectin
Additional Names: Acrp30; adipoQ; GBP28
Literature References: Adipocyte hormone involved in glucose and lipid homeostasis. Consists of an N-terminal collagenous domain and a C-terminal globular domain with sequence homology to complement factor C1q. One of the most abundant proteins in human plasma, ranging from 0.5-30mg/ml; levels are reduced in diabetes and obesity. Discovery in murine adipocytes: P. E. Scherer et al., J. Biol. Chem. 270, 26746 (1995); in human adipose tissue: K. Maeda et al., Biochem. Biophys. Res. Commun. 221, 286 (1996). Isolation and characterization from human plasma: Y. Nakano et al., J. Biochem. (Tokyo) 120, 803 (1996). Review of structure and physiology: T.-S. Tsao et al., Eur. J. Pharmacol. 440, 213-221 (2002); of anti-inflammatory and atheroprotective effects in vascular tissue: B. J. Goldstein, R. Scalia, J. Clin. Endocrinol. Metab. 89, 2563-2568 (2004); of role in insulin resistance: M. Haluzík et al., Physiol. Res. 53, 123-129 (2004).
Adipsin Adlumidine Adlumine Adonitol Adonitoxin

Adiponectin, C1Q and collagen domain containing

PDB rendering based on 1c28.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM: 605441 MGI: 106675 HomoloGene: 3525 GeneCards: ADIPOQ Gene
RNA expression pattern
PBB GE ADIPOQ 207175 at tn.png
More reference expression data
Species Human Mouse
Entrez 9370 11450
Ensembl ENSG00000181092 ENSMUSG00000022878
UniProt Q15848 Q60994
RefSeq (mRNA) NM_001177800 NM_009605
RefSeq (protein) NP_001171271 NP_033735
Location (UCSC) Chr 3:
186.56 – 186.58 Mb
Chr 16:
23.15 – 23.16 Mb
PubMed search [1] [2]

Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein which in humans is encoded by the ADIPOQ gene.[1] It is involved in regulating glucose levels as well as fatty acid breakdown.