Adiponectin

Title: Adiponectin
Additional Names: Acrp30; adipoQ; GBP28
Literature References: Adipocyte hormone involved in glucose and lipid homeostasis. Consists of an N-terminal collagenous domain and a C-terminal globular domain with sequence homology to complement factor C1q. One of the most abundant proteins in human plasma, ranging from 0.5-30mg/ml; levels are reduced in diabetes and obesity. Discovery in murine adipocytes: P. E. Scherer et al., J. Biol. Chem. 270, 26746 (1995); in human adipose tissue: K. Maeda et al., Biochem. Biophys. Res. Commun. 221, 286 (1996). Isolation and characterization from human plasma: Y. Nakano et al., J. Biochem. (Tokyo) 120, 803 (1996). Review of structure and physiology: T.-S. Tsao et al., Eur. J. Pharmacol. 440, 213-221 (2002); of anti-inflammatory and atheroprotective effects in vascular tissue: B. J. Goldstein, R. Scalia, J. Clin. Endocrinol. Metab. 89, 2563-2568 (2004); of role in insulin resistance: M. Haluzík et al., Physiol. Res. 53, 123-129 (2004).
Adipsin Adlumidine Adlumine Adonitol Adonitoxin

Adiponectin, C1Q and collagen domain containing

PDB rendering based on 1c28.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ADIPOQ; ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28
External IDs OMIM: 605441 MGI: 106675 HomoloGene: 3525 GeneCards: ADIPOQ Gene
RNA expression pattern
PBB GE ADIPOQ 207175 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9370 11450
Ensembl ENSG00000181092 ENSMUSG00000022878
UniProt Q15848 Q60994
RefSeq (mRNA) NM_001177800 NM_009605
RefSeq (protein) NP_001171271 NP_033735
Location (UCSC) Chr 3:
186.56 – 186.58 Mb
Chr 16:
23.15 – 23.16 Mb
PubMed search [1] [2]

Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein which in humans is encoded by the ADIPOQ gene.[1] It is involved in regulating glucose levels as well as fatty acid breakdown.