Adrenoglomerulotropin

Title: Adrenoglomerulotropin
CAS Registry Number: 1210-56-6
CAS Name: 2,3,4,9-Tetrahydro-6-methoxy-1-methyl-1H-pyrido[3,4-b]indole
Additional Names: aldosterone-stimulating hormone; ASH; 1-methyl-6-methoxy-1,2,3,4-tetrahydro-2-carboline
Molecular Formula: C13H16N2O
Molecular Weight: 216.28
Percent Composition: C 72.19%, H 7.46%, N 12.95%, O 7.40%
Literature References: Found in extracts of pineal gland tissue: Farrell, Circulation 21, 1009 (1960); Farrell, McIsaac, Arch. Biochem. Biophys. 94, 543 (1961). Synthesis from 5-methoxytryptamine and acetaldehyde: McIsaac, Biochim. Biophys. Acta 52, 607 (1961); Meek et al., Chem. Ind. (London) 1964, 622.
Properties: Crystals, mp 150-151°. uv max (ethanol): 225, 280 nm (log e 4.34, 3.86); (0.1N HCl): 220, 273 nm (log e 4.40, 3.86).
Melting point: mp 150-151°
Absorption maximum: uv max (ethanol): 225, 280 nm (log e 4.34, 3.86); (0.1N HCl): 220, 273 nm (log e 4.40, 3.86)
Adrenolutin Adrenomedullin Aequorin Affinin Aflatoxins B

Aldosterone
Aldosterone-2D-skeletal.svg
Identifiers
CAS number 52-39-1 YesY
PubChem 5839
ChemSpider 5633 YesY
UNII 4964P6T9RB YesY
DrugBank DB04630
KEGG C01780 YesY
MeSH Aldosterone
ChEBI CHEBI:27584 YesY
ChEMBL CHEMBL273453 YesY
ATC code H02AA01
Jmol-3D images Image 1
Properties
Molecular formula C21H28O5
Molar mass 360.44 g mol−1
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Aldosterone is a steroid hormone (mineralocorticoid family) produced by the outer section (zona glomerulosa) of the adrenal cortex in the adrenal gland.[1][2] It plays a central role in the regulation of blood pressure mainly by acting on the distal tubules and collecting ducts of the nephron, increasing reabsorption of ions and water in the kidney, to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure.[1] When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and renal disease.[2] Aldosterone has exactly the opposite function of the atrial natriuretic hormone secreted by the heart.[1]

Drugs that interfere with the secretion or action of aldosterone are in use as antihypertensives, like lisinopril, which lowers blood pressure by blocking the angiotensin-converting enzyme (ACE), leading to lower aldosterone secretion; its net effect is to reduce sodium and water retention but increase retention of potassium. Aldosterone is part of the renin-angiotensin system. Another example is spironolactone, a potassium-sparing diuretic, which decreases blood pressure by releasing fluid from the body while retaining potassium.

It was first isolated by Simpson and Tait in 1953.[3]