Aldioxa

Title: Aldioxa
CAS Registry Number: 5579-81-7
CAS Name: [(2,5-Dioxo-4-imidazolidinyl)ureato]dihydroxyaluminum
Additional Names: (allantoinato)dihydroxyaluminum; dihydroxy[(4,5-dihydro-2-hydroxy-5-oxo-1H-imidazol-4-yl)ureato]aluminum; aluminum dihydroxy allantoinate
Manufacturers' Codes: RC-172
Trademarks: Alanetorin (Takata; Nippon Kayaku); Alusa (Towa Yakuhin); Arlanto (Nichiiko); Ascomp (Nippon Chemiphar); Chlokale (Sawai); Isalon (Grelan); Nische (Kodama); Peptilate (Dojin)
Molecular Formula: C4H7AlN4O5
Molecular Weight: 218.10
Percent Composition: C 22.03%, H 3.24%, Al 12.37%, N 25.69%, O 36.68%
Literature References: Prepn: S. B. Mecca, US 2761867 (1956 to Schuylkill Chem.). Pharmacology: R. Cahen, J. F. Clement, Ann. Pharm. Fr. 20, 693 (1962); R Cahen, A. Pessonnier, ibid. 704. Toxicology: R. Cahen, A. Pessonnier, ibid. 623. Metabolism studies: K. Fukawa et al., Oyo Yakuri 11, 421 (1976), C.A. 88, 130701g (1978). HPLC determn in plasma: K. Hirota et al., J. Chromatogr. 277, 165 (1983). Clinical studies of combination therapy for peptic ulcer: M. Sakai et al., Jpn. Arch. Intern. Med. 31, 275 (1984); idem et al., ibid. 33, 61 (1986); idem et al., ibid. 36, 357 (1989). Review of cosmetic use and safety assessment: S. N. J. Pang, J. Am. Coll. Toxicol. 12, 237-242 (1993).
Properties: White powder. mp 230°. Insol in polar and nonpolar solvents.
Melting point: mp 230°
Use: Astringent and skin conditioning agent in cosmetics.
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative.
Aldol Aldosterone Aldrin Alefacept Alemtuzumab

Allantoin
Allantoïne.JPG
Allantoin chemical structure.png
Identifiers
CAS number 97-59-6 YesY
PubChem 204
ChemSpider 199 YesY
UNII 344S277G0Z YesY
EC number 202-592-8
KEGG D00121 YesY
ChEBI CHEBI:15676 YesY
ChEMBL CHEMBL593429 YesY
RTECS number YT1600000
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C4H6N4O3
Molar mass 158.12 g mol−1
Appearance colourless crystalline powder
Odor odorless
Density 1.45 g/cm3
Melting point 230 °C; 446 °F; 503 K (decomp.)
Boiling point 478 °C; 892 °F; 751 K
Solubility in water 0.57 g/100 mL (25 °C)
4.0 g/100 mL (75 °C)
Solubility soluble in alcohol, pyridine, NaOH
insoluble in ethyl ether
log P -3.14
Acidity (pKa) 8.48
Hazards
MSDS Allantoin MSDS
NFPA 704
NFPA 704.svg
1
2
0
LD50 > 5000 mg/kg (oral, rat)
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Allantoin is a chemical compound with formula C4H6N4O3. It is also called 5-ureidohydantoin or glyoxyldiureide.[1][2] It is a diureide of glyoxylic acid.[citation needed]

Named after the allantois (an amniote embryonic excretory organ in which it concentrates during development in most mammals except humans and higher apes[vague]), it is a product of oxidation of uric acid by purine catabolism. After birth, it is the predominant means by which nitrogenous waste is excreted in the urine of these animals.[3] In humans and higher apes, the metabolic pathway for conversion of uric acid to allantoin is not present, so the former is excreted. Recombinant rasburicase is sometimes used as a drug to catalyze this metabolic conversion in patients. In fish, allantoin is broken down further (into ammonia) before excretion.[4] Allantoin is a major metabolic intermediate in many other organisms including plants and bacteria.