Almotriptan

Title: Almotriptan
CAS Registry Number: 154323-57-6
CAS Name: 1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine
Additional Names: 1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]pyrrolidine
Manufacturers' Codes: LAS-31416
Molecular Formula: C17H25N3O2S
Molecular Weight: 335.46
Percent Composition: C 60.87%, H 7.51%, N 12.53%, O 9.54%, S 9.56%
Literature References: Serotonin 5HT1B/1D-receptor agonist. Prepn: D. F. Forner et al., WO 9402460; eidem, US 5565447 (1994, 1996 both to Almirall). Clinical pharmacokinetics: J. C. Fleishaker et al., Clin. Pharmacol. Ther. 67, 498 (2000). Review of pharmacology: F. Kamali, Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs 2, 197-202 (2000); of clinical studies: D. W. Dodick, Expert Opin. Pharmacother. 4, 1157-1163 (2003).
Derivative Type: Maleate
CAS Registry Number: 181183-52-8
Manufacturers' Codes: PNU-180638E
Trademarks: Almogran (Almirall); Axert (Pharmacia & Upjohn)
Molecular Formula: C17H25N3O2S.C4H6O5
Molecular Weight: 469.55
Percent Composition: C 53.72%, H 6.65%, N 8.95%, O 23.85%, S 6.83%
Properties: White to slightly yellow crystalline powder; sol in water.
Therap-Cat: Antimigraine.
Keywords: Antimigraine; Serotonin Receptor Agonist.
Aloe-Emodin Aloin Alosetron Aloxidone Aloxiprin

Almotriptan
Almotriptan skeletal.svg
Systematic (IUPAC) name
N,N-dimethyl-2- [5-(pyrrolidin-1-ylsulfonylmethyl)- 1H-indol-3-yl]-ethanamine
Clinical data
Trade names Axert
AHFS/Drugs.com monograph
MedlinePlus a603028
Pregnancy cat. C (US)
Legal status Prescription only
Routes Oral
Pharmacokinetic data
Bioavailability 70%
Protein binding 35%
Metabolism Hepatic
Half-life 3–4 hours
Identifiers
CAS number 154323-57-6 N
ATC code N02CC05
PubChem CID 123606
DrugBank DB00918
ChemSpider 110198 YesY
UNII 1O4XL5SN61 YesY
KEGG D02824 YesY
ChEBI CHEBI:520985 YesY
ChEMBL CHEMBL1505 YesY
Chemical data
Formula C17H25N3O2S 
Mol. mass 335.465 g/mol
 N (what is this?)  (verify)

Almotriptan (trade names Axert (US, Canada), Almogran (Belgium, Denmark, Finland, France, Germany, Italy, Ireland Portugal, Spain, the United Kingdom, the Netherlands, Sweden, Switzerland, South Korea… ), Almotrex (Italy) and Amignul (Spain)) is a triptan drug discovered and developed by Almirall for the treatment of heavy migraine headache. It is available in 12.5 mg in most countries and also 6.25 mg in US and Canada.