Althiazide

Title: Althiazide
CAS Registry Number: 5588-16-9
CAS Name: 6-Chloro-3,4-dihydro-3-[(2-propenylthio)methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 3-[(allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-allylthiomethyl-6-chloro-7-sulfamoyl-3,4-dihydrobenzothiadiazine 1,1-dioxide; 6-chloro-3,4-dihydro-7-sulfamoyl-3-(2-thiapent-4-enyl)-2H-1,2,4-benzothiadiazine 1,1-dioxide; altizide
Manufacturers' Codes: P-1779
Molecular Formula: C11H14ClN3O4S3
Molecular Weight: 383.89
Percent Composition: C 34.42%, H 3.68%, Cl 9.24%, N 10.95%, O 16.67%, S 25.06%
Literature References: Prepn: GB 902658; W. M. McLamore, G. D. Laubach, US 3111517 (1962, 1963 both to Pfizer). HPLC determn in tablets: F. DeCroo et al., J. Chromatogr. 329, 422 (1985). Clinical evaluation in hypertension: G. Simon et al., Curr. Ther. Res. 46, 44 (1989).
Properties: Solid, mp 206-207°.
Melting point: mp 206-207°
NOTE: Combination with spironolactone, Aldactazine (Searle) .
Therap-Cat: Diuretic; antihypertensive.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs.
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