Title: Alverine
CAS Registry Number: 150-59-4
CAS Name: N-Ethyl-N-(3-phenylpropyl)benzenepropanamine
Additional Names: N-ethyl-3,3¢-diphenyldipropylamine; bis(g-phenylpropyl)ethylamine; di(phenylpropyl)ethylamine
Molecular Formula: C20H27N
Molecular Weight: 281.44
Percent Composition: C 85.35%, H 9.67%, N 4.98%
Literature References: Prepn: Külz et al., Ber. 72, 2165 (1939); Stühner, Elbrächter, Arch. Pharm. 287, 139 (1954). Physical properties: E. F. Salim, W. R. Ebert, J. Pharm. Sci. 56, 1162 (1967). Clinical trial in irritable bowel syndrome: G. J. Tudor, Br. J. Clin. Pract. 40, 276 (1985).
Properties: Liquid, bp0.3 165-168°; bp13 210-215°.
Boiling point: bp0.3 165-168°; bp13 210-215°
Derivative Type: Citrate
CAS Registry Number: 5560-59-8
Trademarks: Spasmaverine (Bellon); Spasmonal (Norgine)
Molecular Formula: C20H27N.C6H8O7
Molecular Weight: 473.56
Percent Composition: C 65.94%, H 7.45%, N 2.96%, O 23.65%
Properties: White to off-white powder having a sweet odor and slightly bitter taste, mp 100-102°. Slightly sol in water, chloroform; sparingly sol in alcohol; very slightly sol in ether.
Melting point: mp 100-102°
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic.
Alvimopan Amanitin Amanozine Amantadine Amantanium Bromide

Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
Legal status  ?
CAS number 150-59-4 YesY
ATC code A03AX08
PubChem CID 3678
DrugBank DB01616
ChemSpider 3550 YesY
UNII 46TIR1560O YesY
KEGG D07440 YesY
ChEBI CHEBI:518413 YesY
Chemical data
Formula C20H27N 
Mol. mass 281.44 g/mol
 YesY (what is this?)  (verify)

Alverine is a drug used for functional gastrointestinal disorders. Alverine is a smooth muscle relaxant. Smooth muscle is a type of muscle that is not under voluntary control; it is the muscle present in places such as the gut and uterus. Alverine acts directly on the muscle in the gut, causing it to relax. This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease. Diverticular disease is a condition in which small pouches form in the gut lining. These pouches can trap particles of food and become inflamed and painful. In irritable bowel syndrome the normal activity of the gut muscle is lost. The muscle spasms result in symptoms such as heartburn, abdominal pain and bloating, constipation or diarrhoea. By relaxing the gut muscle, alverine citrate relieves the symptoms of this condition. Alverine also relaxes the smooth muscle in the womb (uterus). It is therefore also used to treat painful menstruation, which is caused by muscle spasms in the uterus (dysmenorrhea).