Amperozide

Title: Amperozide
CAS Registry Number: 75558-90-6
CAS Name: 4-[4,4-Bis(4-fluorophenyl)butyl]-N-ethyl-1-piperazinecarboxamide
Manufacturers' Codes: FG-5606
Trademarks: Hogpax (Ferrosan)
Molecular Formula: C23H29F2N3O
Molecular Weight: 401.49
Percent Composition: C 68.81%, H 7.28%, F 9.46%, N 10.47%, O 3.99%
Literature References: Piperazine deriv with effects on stress-induced disorders. Prepn: A. K. K. Björk et al., DE 2941880; US 4308387 (1980, 1981 both to Ferrosan). Effects on psychosomatic disorders in man: E. Christensson et al., 3rd World Congr. Biol. Psychiatr., Abstr. F 78 (Stockholm, 1981). Clinical effects in pig prodn: A. Björk et al., Proc. Int. Pig Vet. Soc. Congr., pp 315, 316, 317 (Mexico, 1982).
Derivative Type: Hydrochloride
Molecular Formula: C23H30ClF2N3O
Molecular Weight: 437.95
Percent Composition: C 63.08%, H 6.90%, Cl 8.10%, F 8.68%, N 9.59%, O 3.65%
Properties: mp 177-178°.
Melting point: mp 177-178°
Therap-Cat-Vet: Anti-aggressive.
Amphecloral Amphenidone Amphenone B Amphetaminil Amphomycin

Amperozide
Amperozide.png
Systematic (IUPAC) name
4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide
Clinical data
Legal status  ?
Identifiers
CAS number 75558-90-6 YesY
ATCvet code QN05AX90
PubChem CID 73333
ChemSpider 66062 YesY
UNII 0M2W3TAG39 YesY
ChEMBL CHEMBL1079935 YesY
Chemical data
Formula C23H29F2N3O 
Mol. mass 401.493 g/mol
 YesY (what is this?)  (verify)

Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT2A receptor.[1] It does not block dopamine receptors as with most antipsychotic drugs,[2] but does inhibit dopamine release,[3][4] and alters the firing pattern of dopaminergic neurons.[5] It was investigated for the treatment of schizophrenia in humans,[6] but never adopted clinically, its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity.[7][8][9]