Title: Amphetaminil
CAS Registry Number: 17590-01-1
CAS Name: a-[(1-Methyl-2-phenylethyl)amino]benzeneacetonitrile
Additional Names: N-(a-methylphenethyl)-2-phenylglycinonitrile; a-phenyl-a-(b-phenylisopropylamino)acetonitrile; a-phenyl-a-(1-methyl-2-phenyl)ethylaminoacetonitrile; a-phenyl-a-N-(1-phenylisopropyl)aminoacetonitrile
Trademarks: AN 1 (Krugmann); Aponeuron (Apogepha)
Molecular Formula: C17H18N2
Molecular Weight: 250.34
Percent Composition: C 81.56%, H 7.25%, N 11.19%
Literature References: Prepd by reaction of DL-b-phenylisopropylamine with sodium cyanide and benzaldehyde or with a-phenyl-a-bromoacetonitrile: Klosa, DE 1112987 (1959), C.A. 56, 3409d (1962); idem, J. Prakt. Chem. 20, 275 (1963). Pharmacology: Dominok, Oelssner, Acta Biol. Med. Ger. 20, 625 (1968); Beyer et al., Dtsch. Apoth. Ztg. 111, 677, 680 (1971). Metabolic studies: Remberg et al., Arch. Toxicol. 29, 153 (1972). Chemistry: Beyrich et al., Pharmazie 27, 28 (1972); Gloeckl, Beyrich, ibid. 95.
Properties: Crystals from ethanol-water, mp 85-87°.
Melting point: mp 85-87°
Derivative Type: Hydrochloride
Molecular Formula: C17H19ClN2
Molecular Weight: 286.80
Percent Composition: C 71.19%, H 6.68%, Cl 12.36%, N 9.77%
Properties: Sinters at 100-104°, mp 134-136°.
Melting point: mp 134-136°
Therap-Cat: Psychotropic.
Keywords: CNS Stimulant.
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Amphetaminil Structural Formulae.png
Systematic (IUPAC) name
Clinical data
Legal status  ?
CAS number 17590-01-1
ATC code None
PubChem CID 28615
ChemSpider 26613 YesY
KEGG D07446 YesY
Chemical data
Formula C17H18N2 
Mol. mass 250.338
 YesY (what is this?)  (verify)

Amphetaminil (Aponeuron, AN-1) is a stimulant drug derived from amphetamine, which was developed in the 1970s and used for the treatment of obesity,[1] ADHD,[2][3] and narcolepsy.[4] It has largely been withdrawn from clinical use following problems with abuse.[5]