|Angiogenin, ribonuclease, RNase A family, 5|
Ribonuclease inhibitor-angiogenin complex. From PDB 1a4y
|Symbols||ANG (; ALS9; HEL168; RNASE4; RNASE5)|
|External IDs||ChEMBL: GeneCards:|
Angiogenin (Ang) also known as ribonuclease 5 is a small 123 amino acid protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator of new blood vessels through the process of angiogenesis. Ang hydrolyzes cellular RNA, resulting in modulated levels of protein synthesis and interacts with DNA causing a promoter-like increase in the expression of rRNA. Ang is associated with cancer and neurological disease through angiogenesis and through activating gene expression that suppresses apoptosis.