Angiogenin

Title: Angiogenin
Literature References: Single-chain, basic protein of 123 amino acids that induces the in vivo formation of blood vessels. Mol wt ~14,000 Da. First isolated from human adenocarcinoma cells; subsequently found in normal human plasma and shown to be produced by the liver. Angiogenin exhibits a characteristic ribonucleolytic activity toward 28S and 18S ribosomal RNA. Its amino acid sequence is 35% identical with that of human pancreatic ribonuclease. Isoln, characterization, and angiogenic activity: J. W. Fett et al., Biochemistry 24, 5480 (1985). Amino acid sequence: D. J. Strydom et al., ibid. 5486. Cloning and DNA sequence of human angiogenin gene: K. Kurachi et al., ibid. 5494. Structural study: K. A. Palmer et al., Proc. Natl. Acad. Sci. USA 83, 1965 (1986). Ribonucleolytic activity: R. Shapiro et al., Biochemistry 25, 3527 (1986). Isoln from normal human plasma: R. Shapiro et al., ibid. 26, 5141 (1987). Tissue distribution in neonatal and adult rats: H. L. Weiner et al., Science 237, 280 (1987); in human tumor and normal cells: S. M. Rybak et al., Biochem. Biophys. Res. Commun. 146, 1240 (1987). Inhibition of protein synthesis: D. K. St. Clair et al., Proc. Natl. Acad. Sci. USA 84, 8330 (1987). Inhibition of angiogenic and ribonucleolytic activities of angiogenin by placental ribonuclease inhibitor: R. Shapiro, B. L. Vallee, ibid. 2238; F. S. Lee, B. L. Vallee, Biochemistry 28, 3556 (1989). Reviews: J. F. Riordan, B. L. Vallee, Br. J. Cancer 57, 587-590 (1988); B. L. Vallee, J. F. Riordan, Adv. Exp. Med. Biol. 234, 41-53 (1988).
Angiostatin Angostura Bark Anhalamine Anhalonidine Anhalonine

Angiogenin, ribonuclease, RNase A family, 5

Ribonuclease inhibitor-angiogenin complex. From PDB 1a4y
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ANG (; ALS9; HEL168; RNASE4; RNASE5)
External IDs OMIM: 105850 MGI: 88022 HomoloGene: 74385 ChEMBL: 5829 GeneCards: ANG Gene
EC number 3.1.27.-
Orthologs
Species Human Mouse
Entrez 283 11727
Ensembl ENSG00000214274 ENSMUSG00000072115
UniProt P03950 P21570
RefSeq (mRNA) NM_001097577 NM_001161731
RefSeq (protein) NP_001091046 NP_001155203
Location (UCSC) Chr 14:
21.15 – 21.17 Mb
Chr 14:
51.09 – 51.1 Mb
PubMed search [1] [2]

Angiogenin (Ang) also known as ribonuclease 5 is a small 123 amino acid protein that in humans is encoded by the ANG gene.[1] Angiogenin is a potent stimulator of new blood vessels through the process of angiogenesis. Ang hydrolyzes cellular RNA, resulting in modulated levels of protein synthesis and interacts with DNA causing a promoter-like increase in the expression of rRNA.[2][3] Ang is associated with cancer and neurological disease through angiogenesis and through activating gene expression that suppresses apoptosis.[2][4][5]