Angiostatin

Title: Angiostatin
Literature References: Naturally occurring inhibitor of angiogenesis that suppresses the growth of primary and metastatic tumors. 38 kDa protein generated by the cancer-mediated proteolysis of plasminogen, q.v.; amino acid sequence corresponds to the first four kringle domains. Isoln, amino acid sequence and bioactivity: M. S. O'Reilly et al., Cell 79, 315 (1994). Review of discovery: R. Vile, Curr. Biol. 5, 10-13 (1995). Effect on human carcinomas in mice: M. S. O'Reilly et al., Nat. Med. 2, 689 (1996). Mechanism of angiostatin generation: S. Gately et al., Proc. Natl. Acad. Sci. USA 94, 10868 (1997).
Angostura Bark Anhalamine Anhalonidine Anhalonine Anidulafungin

Angiostatin is a naturally occurring protein found in several animal species, including humans. It is an endogenous angiogenesis inhibitor (i.e., it blocks the growth of new blood vessels), and it is currently undergoing clinical trials for its use in anticancer therapy.[1]