Anisindione

Title: Anisindione
CAS Registry Number: 117-37-3
CAS Name: 2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione
Additional Names: 2-p-anisyl-1,3-indandione; 2-(p-methoxyphenyl)-1,3-indandione
Manufacturers' Codes: SPE-2792
Trademarks: Miradon (Schering); Unidone (Schering)
Molecular Formula: C16H12O3
Molecular Weight: 252.26
Percent Composition: C 76.18%, H 4.79%, O 19.03%
Literature References: Prepn: Koelsch, J. Am. Chem. Soc. 58, 1331 (1936); Horeau, Jacques, Bull. Soc. Chim. Fr. 1948, 53; Sperber, US 2899358 (1959 to Schering).
Properties: Pale yellow crystals from acetic acid or ethanol, mp 156-157°.
Melting point: mp 156-157°
Therap-Cat: Anticoagulant.
Keywords: Anticoagulant.
Anisole Anisomycin Anisotropine Methylbromide Anistreplase Annatto

Anisindione
Anisindione skeletal.svg
Systematic (IUPAC) name
2-(4-methoxyphenyl)indene-1,3-dione
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Legal status  ?
Routes Oral
Identifiers
CAS number 117-37-3 YesY
ATC code None
PubChem CID 2197
DrugBank DB01125
ChemSpider 2112 YesY
UNII S747T1ERAJ YesY
KEGG D07457 YesY
ChEBI CHEBI:133809 YesY
ChEMBL CHEMBL712 YesY
Chemical data
Formula C16H12O3 
Mol. mass 252.265 g/mol
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Anisindione (brand name Miradon) is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins.