CAS Registry Number: 81669-57-0
Additional Names: Anisoylated plasminogen streptokinase activator complex; APSAC
Manufacturers' Codes: BRL-26921
Trademarks: Eminase (SKB); Multilase (Sigma-Tau)
Literature References: Binary complex of streptokinase and human plasminogen in which the catalytic site is reversibly blocked by a p-methoxybenzoyl group without affecting the fibrin-binding site. Prepn and fibrinolytic activity: R. A. G. Smith, J. G. Winchester, EP 28489; eidem, US 4808405 (1981, 1989 both to Beecham). Deacylation of the fibrin-bound complex initiates thrombolysis: R. A. G. Smith et al., Nature 290, 505 (1981); D. Matsuo et al., Thromb. Res. 24, 347 (1981). Effect on hemostasis in humans: D. H. Staniforth et al., Eur. J. Clin. Pharmacol. 24, 751 (1983). Pharmacokinetics: M. Been et al., Int. J. Cardiol. 11, 53 (1986). Evaluation of thrombolytic efficacy in myocardial infarction: W. Kasper et al., Am. J. Cardiol. 58, 418 (1986); in major pulmonary embolism: J. H. Brett et al., Aust. N.Z. J. Med. 17, 77 (1987). Controlled clinical trial in acute myocardial infarction: S. Ikram et al., Br. Med. J. 293, 786 (1986). Review of mechanism of action, pharmacology and therapeutic use: J. P. Monk, R. C. Heel, Drugs 34, 25-49 (1987).