Title: Aprindine
CAS Registry Number: 37640-71-4
CAS Name: N-(2,3-Dihydro-1H-inden-2-yl)-N¢,N¢-diethyl-N-phenyl-1,3-propanediamine
Additional Names: N,N-diethyl-N¢-2-indanyl-N¢-phenyl-1,3-propanediamine; N-[3-(diethylamino)propyl]-N-phenyl-2-indanamine
Manufacturers' Codes: compd 99170; AC-1802; Lilly 99170
Molecular Formula: C22H30N2
Molecular Weight: 322.49
Percent Composition: C 81.94%, H 9.38%, N 8.69%
Literature References: Membrane-stabilizing agent. Prepn: P. M. Vanhoof, P. M. Clarebout, BE 760018; eidem, US 3923813 (1971, 1975 both to Christiaens). Toxicological study: A. Georges et al., Arzneim.-Forsch. 23, 519 (1973). Pharmacokinetics: T. Kobari et al., Eur. J. Clin. Pharmacol. 26, 129 (1984). HPLC determn in plasma: T. Kobari et al., J. Chromatogr. 278, 220 (1983). Clinical studies: D. P. Zipes et al., Am. J. Cardiol. 40, 586 (1977); P. J. Troup, D. P. Zipes, Am. Heart J. 97, 322 (1979). Reviews: P. Danilo, ibid. 119; I. Stoel, S. F. Hagemeijer, Eur. Heart J. 1, 147 (1980).
Derivative Type: Hydrochloride
CAS Registry Number: 33237-74-0
Manufacturers' Codes: Compd 83846
Trademarks: Amidonal (PCR Arzneimittel); Aspenon (Mitsui); Fiboran (Christiaens); Ritmusin (Gebro)
Molecular Formula: C22H30N2.HCl
Molecular Weight: 358.95
Percent Composition: C 73.61%, H 8.70%, N 7.80%, Cl 9.88%
Properties: Crystals from benzene, mp 120-121°.
Melting point: mp 120-121°
Therap-Cat: Antiarrhythmic (class I).
Keywords: Antiarrhythmic.
Aprinocarsen Aprobarbital Apronalide Aprotinin Aptiganel

Systematic (IUPAC) name
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
CAS number 37640-71-4
ATC code C01BB04
PubChem CID 2218
DrugBank DB01429
ChemSpider 2132 YesY
UNII 5Y48085P9Q YesY
KEGG D02969 YesY
Chemical data
Formula C22H30N2 
Mol. mass 322.487 g/mol
 YesY (what is this?)  (verify)

Aprindine is a Class 1b antiarrhythmic agent.[1]

In one study, it delayed atrial fibrillation more than digoxin did.[2]

It has shown effectiveness when given orally.[3]