Arsthinol

Title: Arsthinol
CAS Registry Number: 119-96-0
CAS Name: N-[2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]acetamide
Additional Names: 3-acetamido-4-hydroxydithiobenzenearsonous acid, cyclic (hydroxymethyl)ethylene ester; 2-(3¢-acetamido-4¢-hydroxyphenyl)-1,3-dithia-2-arsacyclopentane-4-methanol; 3-acetamido-4-hydroxydithiobenzenearsonous acid cyclic 3-hydroxypropylene ester; 2-acetylamino-4-(methylolcycloethylenedimercaptoarsine)phenol
Trademarks: Balarsen
Molecular Formula: C11H14AsNO3S2
Molecular Weight: 347.29
Percent Composition: C 38.04%, H 4.06%, As 21.57%, N 4.03%, O 13.82%, S 18.47%
Literature References: Trivalent arsenical; derivative of acetarsone, q.v. Prepn: Friedheim, US 2593434 (1952); US 2772303 (1956).
Properties: Minute crystals, mp 163-166°. Soly in 95% ethanol about 2.7% w/v. Very slightly sol in water, ether.
Melting point: mp 163-166°
Therap-Cat: Antiamebic.
Keywords: Antiamebic.
Arteether Arteflene Artemether Artesunate ar-Turmerone

Arsthinol
Structural formula of arsthinol
Identifiers
CAS number 119-96-0 N
PubChem 8414
ChemSpider 8107 YesY
EC number 204-361-7
KEGG D07356 YesY
ATC code P01AR01,QP51AD01
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C11H14AsNO3S2
Molar mass 347.29 g mol−1
Pharmacology
Routes of
administration
Oral
Metabolism 89 % Hepatic[1]
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Arsthinol (INN) is an antiprotozoal agent. It was synthesized for the first time in 1949 by Ernst A.H. Friedheim by complexation of acetarsol with 2,3-dimercaptopropanol (British anti-Lewisite)[2] and has been demonstrated to be effective against amoebiasis and yaws. It was marketed few years latter by Endo Products (Balarsen, Tablets, 0.1 g).[3] Among trivalent organoarsenicals, arthinol was considered as very well tolerated.[4] Recently, it was studied for its anticancer activity.[5][6]