Arteether

Title: Arteether
CAS Registry Number: 75887-54-6
CAS Name: (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
Additional Names: dihydroartemisinin ethyl ether; dihydroqinghaosu ethyl ether; artemotil
Manufacturers' Codes: SM-227
Molecular Formula: C17H28O5
Molecular Weight: 312.40
Percent Composition: C 65.36%, H 9.03%, O 25.61%
Literature References: Derivative of artemisinin, q.v. Prepn: Y. Li et al., Acta Pharm. Sin. 16, 429 (1981). Synthesis and antimalarial activity: China Cooperative Research Group on Qinghaosu, J. Tradit. Chin. Med. 2, 9 (1982); A. Brossi et al., J. Med. Chem. 31, 645 (1988).
Properties: White crystalline solid, mp 80-82°. [a]D21 +154.5° (c = 1.0 in CHCl3).
Melting point: mp 80-82°
Optical Rotation: [a]D21 +154.5° (c = 1.0 in CHCl3)
Therap-Cat: Antimalarial.
Keywords: Antimalarial.
Arteflene Artemether Artesunate ar-Turmerone Arylsulfatase B

Artemotil
Artemotil.svg
Systematic (IUPAC) name
(5aS,6R,8aS,9R,10S,12R,12aR)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat. not available
Legal status  ?
Routes Intramuscular injection
Pharmacokinetic data
Metabolism Hepatic
Half-life 20 hours
Identifiers
CAS number 75887-54-6 N
ATC code P01BE04
PubChem CID 72416
ChemSpider 16735673 YesY
UNII XGL7GFB9YI YesY
ChEMBL CHEMBL301267 N
Chemical data
Formula C17H28O5 
Mol. mass 312.401 g/mol
 N (what is this?)  (verify)

Artemotil (INN; also known as β-arteether), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria.