|Systematic (IUPAC) name|
|Mol. mass||173.127 g/mol|
|(what is this?)|
Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumor agent, Azaserine is used in clinical studies as a potential antineoplastic agent
•Description Azaserine is an inhibitor of the rate limiting step of the hexosamine biosynthethic pathway (HBP) and an irreversible inhibitor of GGT1 (gamma-Glutamyltranspeptidase). Independent of inhibiting the HBP pathway, azarine studies have demonstrated that it can protect against hyperglycemic endothelial damage through its antioxidant effect. Azarine and acivicin (sc-200498), another GGT inhibitor, bind to GGT at its substrate-binding pocket. The compound has been shown to elevate the SOD-2 (manganese-superoxide dismutase (MnSOD)) protein level as well as inhibit the oxidative stress and the expression of VCAM-1 and ICAM-1 in response to TNFα. Research indicates that azaserine has the potential to be used as a probe for identifying the L-(leucine-favoring) system transporter in human T-lymphocytes
•Specifications Purity: ≥98%Physical Appearance: White to yellow to powder•Properties Molecular Weight: 173.127Molecular Formula: C5H7N3O4Form: SolidSolubility: Soluble in water (50 mg/ml), Slightly soluble in methanol, and absolute alcohol.Melting Point: 146-162 °C (dec.)Boling Point: 589.73 °C (Predicted)Vapor Pressure: 1.53 x 10-10 mmHg at 25 °C
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