Beclotiamine

Title: Beclotiamine
CAS Registry Number: 13471-78-8
CAS Name: 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-chloroethyl)-4-methylthiazolium chloride
Additional Names: 5-chloroethylthiamine; chlorothiamine; clotiamine; CT
Trademarks: Cocciden (Sankyo)
Molecular Formula: C12H16Cl2N4S
Molecular Weight: 319.25
Percent Composition: C 45.15%, H 5.05%, Cl 22.21%, N 17.55%, S 10.04%
Literature References: Antithiamine compound derived from thiamine; developed as an anticoccidial for chickens: Inone et al., J. Jpn. Vet. Med. Assoc. 20, 293 (1967); GB 1141055; M. Nagawa et al., US 3786147 (1969, 1974 both to Sankyo); Matsuzawa, Jpn. J. Vet. Sci. 34, 157 (1972), C.A. 78, 23930c (1973). Metabolism and mechanism of action studies: Shindo, Komai, J. Vitaminol. 18, 41-62, 102, 172, 218 (1972). Safety studies: Matsuzawa et al., Sankyo Kenkyusho Nempo 23, 192 (1971), C.A. 77, 28983m (1972).
Derivative Type: Hydrochloride
Molecular Formula: C12H17Cl3N4S
Molecular Weight: 355.71
Percent Composition: C 40.52%, H 4.82%, Cl 29.90%, N 15.75%, S 9.01%
Derivative Type: Naphthalene-1,5-disulfonate salt
Molecular Formula: C22H24Cl2N4O6S3
Molecular Weight: 607.55
Percent Composition: C 43.49%, H 3.98%, Cl 11.67%, N 9.22%, O 15.80%, S 15.83%
Properties: mp 276° (dec). Soly in water: 0.06 g/100 ml.
Melting point: mp 276° (dec)
Therap-Cat-Vet: Coccidiostat.
Status: This monograph has been retired and is no longer subject to revision or update.
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