Benactyzine

Title: Benactyzine
CAS Registry Number: 302-40-9
CAS Name: a-Hydroxy-a-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester
Additional Names: benzilic acid b-diethylaminoethyl ester; b-diethylaminoethyl benzilate; 2-diethylaminoethyl diphenylglycolate
Molecular Formula: C20H25NO3
Molecular Weight: 327.42
Percent Composition: C 73.37%, H 7.70%, N 4.28%, O 14.66%
Literature References: An antagonist of acetylcholine in the central and peripheral nervous systems. Prepn: Horenstein, Pahlicke, Ber. 71, 1654 (1938); Blicke, Maxwell, J. Am. Chem. Soc. 64, 428 (1942); Hill, Holmes, US 2394770 (1946 to Am. Cyanamid). Toxicity and pharmacodynamics: Fournier, Petit, Therapie 17, 1245 (1962). Metabolism: Eldeson et al., Arch. Int. Pharmacodyn. Ther. 187, 139 (1970). Crystal and molecular structure determn by x-ray diffraction: T. J. Petcher, J. Chem. Soc. Perkin Trans. 2 1974, 1151.
Properties: Crystals, mp 51°.
Melting point: mp 51°
Derivative Type: Hydrochloride
CAS Registry Number: 57-37-4
Manufacturers' Codes: AY-5406-1
Trademarks: Cedad (Recordati); Nutinal (Boots); Parasan; Suavitil (Merck & Co.)
Molecular Formula: C20H25NO3.HCl
Molecular Weight: 363.88
Percent Composition: C 66.01%, H 7.20%, N 3.85%, O 13.19%, Cl 9.74%
Properties: Crystals from acetone, mp 177-178°. Soly in water (25°): 14.9/100 ml. Practically insol in ether.
Melting point: mp 177-178°
Derivative Type: Methobromide
CAS Registry Number: 3166-62-9
Trademarks: Spatomac
Molecular Formula: C20H25NO3.CH3Br
Molecular Weight: 422.36
Percent Composition: C 59.72%, H 6.68%, N 3.32%, O 11.36%, Br 18.92%
Properties: Crystals from alcohol + ether, mp 169-170°.
Melting point: mp 169-170°
Therap-Cat: Antispasmodic.
Keywords: Antimuscarinic; Antispasmodic.
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Benactyzine
Benactyzine.svg
Systematic (IUPAC) name
2-(diethylamino)ethyl hydroxy(diphenyl)acetate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status Prescription only
Routes Oral
Identifiers
CAS number 302-40-9 YesY
ATC code None
PubChem CID 9330
ChemSpider 8966 YesY
UNII 595EG71R3F YesY
KEGG D07498 YesY
ChEMBL CHEMBL70352 YesY
Chemical data
Formula C20H25NO3 
Mol. mass 327.417 g/mol
 YesY (what is this?)  (verify)

Benactyzine (Suavitil, Phebex, Phobex, Cedad, Cevanol, Deprol, Lucidil, Morcain, Nutinal, Parasan) is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety.[1] However, its use for these indications is limited by side effects such as dry mouth and nausea, and at high doses it can cause more severe symptoms such as deliriant and hallucinogenic effects. Consequently, it is no longer widely used in medicine, although it is still a useful drug for scientific research. It does not possess any antihistamine properties.