Benexate Hydrochloride

Title: Benexate Hydrochloride
CAS Registry Number: 78718-25-9
CAS Name: 2-[[[trans-4-[[(Aminoiminomethyl)amino]methyl]cyclohexyl]carbonyl]oxy]benzoic acid phenylmethyl ester monohydrochloride
Additional Names: benzyl salicylate trans-4-(guanidinomethyl)cyclohexanecarboxylate hydrochloride; (2¢-benzyloxycarbonyl)phenyl trans-4-(guanidinomethyl)cyclohexanecarboxylate hydrochloride
Molecular Formula: C23H28ClN3O4
Molecular Weight: 445.94
Percent Composition: C 61.95%, H 6.33%, Cl 7.95%, N 9.42%, O 14.35%
Literature References: Synthetic protease inhibitor with antiulcer activity. Prepn: BE 885263; M. Muramatsu et al., US 4348410 (1981, 1982 to Nippon Chemiphar; Teikoku Chem. Ind.). Prepn and protease inhibition: T. Satoh et al., Chem. Pharm. Bull. 33, 647 (1985). Prepn of the clathrate compound with b-cyclodextrin: JP Kokai 83 38250; M. Shinoda et al., US 4478995 (1983, 1984 both to Teikoku Chem. Ind.). Effect on gastric secretion and exptl ulcers in rats: S. Okabe et al., Oyo Yakuri 27, 829 (1984), C.A. 101, 143881c (1984); I. Tanaka, H. Tagami, Nippon Yakurigaku Zasshi 85, 167 (1985), C.A. 103, 64660t (1985); F. Hirose et al., Yakuri to Chiryo 15, 4749 (1987), C.A. 108, 137769a (1988).
Properties: Crystals from methanol + ether, mp 83°.
Melting point: mp 83°
Derivative Type: Compd with b-cyclodextrin (1:1)
CAS Registry Number: 91574-91-3
Additional Names: Benexate-CD
Manufacturers' Codes: TA-903
Trademarks: Lonmiel (Teikoku); Ulgut (Shionogi)
Molecular Formula: C65H98ClN3O39
Molecular Weight: 1580.92
Percent Composition: C 49.38%, H 6.25%, Cl 2.24%, N 2.66%, O 39.47%
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Cytoprotectant (Gastric).
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