Benorylate

Title: Benorylate
CAS Registry Number: 5003-48-5
CAS Name: 2-(Acetyloxy)benzoic acid 4-(acetylamino)phenyl ester
Additional Names: salicylic acid acetate, ester with 4-hydroxyacetanilide; 2-acetoxy-4¢-(acetamino)phenylbenzoate; p-acetamidophenyl acetylsalicylate; 4¢-(acetamido)phenyl-2-acetoxybenzoate; fenasprate
Manufacturers' Codes: Win-11450
Trademarks: Benoral (Sanofi Winthrop); Benortan (Sanofi Winthrop); Salipran (Evans)
Molecular Formula: C17H15NO5
Molecular Weight: 313.30
Percent Composition: C 65.17%, H 4.83%, N 4.47%, O 25.53%
Literature References: Prepn: NL 6504517 (1965 to Sterwin), C.A. 64, 8097c (1966), corresp to GB 1101747 (1968); Robertson, US 3431293 and Miller, GB 1168289 (both 1969 to Sterling Drug). Pharmacological investigations: Rosner et al., Therapie 23, 525 (1968); Raab, Arzneim.-Forsch. 21, 1662 (1971). Pharmacokinetic studies in animals: Liss, Palme, ibid. 19, 1177 (1969). Clinical evaluation: Bain, Burt, Clin. Trials J. 7, 307 (1970); Cardoe, ibid. 313.
Properties: Crystals from methanol or ethanol, mp 175-176°. LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson).
Melting point: mp 175-176°
Toxicity data: LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson)
Therap-Cat: Analgesic; anti-inflammatory; antipyretic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic.
Benoxacor Benoxaprofen Benoxinate Benperidol Benproperine

Benorilate
Benorilate.svg
Systematic (IUPAC) name
4-(acetylamino)phenyl 2-(acetyloxy)benzoate
Clinical data
Legal status  ?
Routes Oral
Identifiers
CAS number 5003-48-5 N
ATC code N02BA10
PubChem CID 21102
ChemSpider 19846 N
UNII W1QX9DV96G YesY
ChEMBL CHEMBL162036 N
Chemical data
Formula C17H15NO5 
Mol. mass 313.305 g/mol
 N (what is this?)  (verify)

Benorilate (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1]