Benoxinate

Title: Benoxinate
CAS Registry Number: 99-43-4
CAS Name: 4-Amino-3-butoxybenzoic acid 2-(diethylamino)ethyl ester
Additional Names: 3-butoxy-4-aminobenzoic acid 2-(diethylamino)ethyl ester; 2-(diethylamino)ethyl 4-amino-3-n-butoxybenzoate; oxibuprokain; oxybuprocaine
Molecular Formula: C17H28N2O3
Molecular Weight: 308.42
Percent Composition: C 66.20%, H 9.15%, N 9.08%, O 15.56%
Literature References: Prepn: GB 654484 (1951 to Wander).
Properties: bp2 215-218°.
Boiling point: bp2 215-218°
Derivative Type: Hydrochloride
CAS Registry Number: 5987-82-6
Trademarks: Conjuncain (Mann); Cebesine (Chauvin); Novesine (CIBA Vision); Benoxil (Santen); Lacrimin (Santen)
Molecular Formula: C17H28N2O3.HCl
Molecular Weight: 344.88
Percent Composition: C 59.20%, H 8.48%, N 8.12%, O 13.92%, Cl 10.28%
Properties: Crystals, mp ~155° (U.S.P. XVI, 1960), also reported as mp 157-160° (N.N.R. 1955). Very sol in water, chloroform; sol in alc. Practically insol in ether. pH of aq solns, 4.5-5.2.
Melting point: mp ~155° (U.S.P. XVI, 1960); mp 157-160° (N.N.R. 1955)
Therap-Cat: Anesthetic (local).
Keywords: Anesthetic (Local).
Benperidol Benproperine Benserazide Bensuldazic Acid Bensulfuron-methyl

Oxybuprocaine
Oxybuprocaine.svg
Systematic (IUPAC) name
2-diethylaminoethyl 4-amino-3-butoxy-benzoate
Clinical data
Trade names Novesin(e)
AHFS/Drugs.com International Drug Names
Pregnancy cat. D (AU)
Legal status  ?
Routes Topical
Pharmacokinetic data
Metabolism Esterases in blood plasma and liver
Identifiers
CAS number 99-43-4 YesY
ATC code D04AB03 S01HA02
PubChem CID 4633
DrugBank DB00892
ChemSpider 4472 YesY
UNII AXQ0JYM303 YesY
KEGG D08319 YesY
ChEBI CHEBI:309594 YesY
ChEMBL CHEMBL1200 YesY
Chemical data
Formula C17H28N2O3 
Mol. mass 308.41 g/mol
 YesY (what is this?)  (verify)

Oxybuprocaine (INN), also known as benoxinate or BNX, is an ester-type local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine is sold by Novartis under the brand names Novesine or Novesin.

Safety for use in pregnancy and lactation has not been established.