Benperidol

Title: Benperidol
CAS Registry Number: 2062-84-2
CAS Name: 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
Additional Names: 1-[1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl]-2-benzimidazolinone; 1-[1-[4-(p-fluorophenyl)-4-oxobutyl]piperidin-4-yl]-2-benzimidazolinone; benzperidol
Manufacturers' Codes: McN-JR-4584; R-4584
Trademarks: Anquil (Janssen-Cilag); Frénactil (Janssen-Cilag); Glianimon (Bayer)
Molecular Formula: C22H24FN3O2
Molecular Weight: 381.44
Percent Composition: C 69.27%, H 6.34%, F 4.98%, N 11.02%, O 8.39%
Literature References: Prepn: BE 626307 (1963 to Janssen), C.A. 60, 10690c (1964), corresp. to GB 989755.
Properties: Solid, mp 170-171.8°.
Melting point: mp 170-171.8°
Derivative Type: Hydrochloride hydrate
Properties: Solid, mp 134-142°.
Melting point: mp 134-142°
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Butyrophenones.
Benproperine Benserazide Bensuldazic Acid Bensulfuron-methyl Bentazon

Benperidol
Benperidol.svg
Systematic (IUPAC) name
1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
Clinical data
AHFS/Drugs.com International Drug Names
Legal status -only (US)
Routes Oral
Identifiers
CAS number 983-42-6 N
ATC code N05AD07
PubChem CID 16363
ChemSpider 15521 YesY
UNII 97O6X78C53 YesY
ChEMBL CHEMBL297302 YesY
Chemical data
Formula C22H24FN3O2 
Mol. mass 381.443 g/mol
 N (what is this?)  (verify)

Benperidol is a drug which is a highly potent butyrophenone derivative. It is in fact the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).[1] It is an antipsychotic, which can be used for the treatment of schizophrenia,[2] but it is primarily used to control antisocial hypersexual behaviour,[3] and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone.[4]

Benperidol was discovered at Janssen Pharmaceutica in 1961.