Benzalkonium Chloride

Title: Benzalkonium Chloride
CAS Registry Number: 8001-54-5
CAS Name: Alkylbenzyldimethyl quaternary ammonium compounds chlorides
Additional Names: alkyldimethyl(phenylmethyl)ammonium chloride
Trademarks: Baktonium (Bode); Benirol (Linobion); Bradosol (Novartis); Callusolve (Dermal); Capitol (Dermal); Laudamonium (Henkel); Osvan (Takeda); Pharmatex (Innothža); Roccal (Sanofi-Synthelabo); Sagrotan (Schke & Mayr); Zephiran (Sanofi-Synthelabo); Zephirol (Bayer)
Literature References: A mixture of alkyldimethylbenzylammonium chlorides; three major homologues consist of C12, C14 and C16 straight chain alkyls. Prepn and biological activity: R. A. Cutler et al., Proc. Annu. Meet. Chem. Spec. Manuf. Assoc. 1966, 102. Acute toxicity data: L. M. Cummins, E. T. Kimura, Toxicol. Appl. Pharmacol. 20, 89 (1971). Capillary electrophoretic determn in formulations: M. Jimidar et al., Biomed. Chromatogr. 12, 128 (1998); MS determn on skin: S. Kawakami et al., Analyst 123, 489 (1998). Efficacy as disinfecting wound irrigant: B. B. Tarbox et al., Clin. Orthop. Relat. Res. 1998, 255. Use as disinfectant against viruses: A. Wood, D. Payne, J. Hosp. Infect. 38, 283 (1998). Brief review: A. C. S. Parr et al., Spec. Chem. 16, 157-160 (1996).
Properties: White or yellowish-white, amorphous powder or gelatinous pieces. Very sol in water, alcohol, acetone; slightly sol in benzene. Almost insol in ether. The aq soln is slightly alkaline to litmus and foams strongly when shaken. LD50 orally in rats: 400 mg/kg (Cummins, Kimura).
Toxicity data: LD50 orally in rats: 400 mg/kg (Cummins, Kimura)
Use: Cationic surface active agent and germicide. Pharmaceutic aid (preservative). Algicide.
Therap-Cat: Antiseptic, disinfectant.
Therap-Cat-Vet: Antiseptic for skin preoperatively or for wounds, burns, etc. Udder wash.
Keywords: Antiseptic/Disinfectant; Quaternary Ammonium Compounds.
Benzamide Benzanilide Benzanthrone Benzarone Benzathine

Benzalkonium chloride
Benzalkonium chloride Structure V.1.svg
Identifiers
CAS number 68424-85-1 N
UNII F5UM2KM3W7 YesY
EC number 264-151-6
KEGG D00857 YesY
ATC code D08AJ01, D09AA11 (dressing), R02AA16
Properties
Molecular formula variable
Molar mass variable
Appearance 100% is white or yellow powder; gelatinous lumps; Solutions BC50 (50%) & BC80 (80%) are colorless to pale yellow solutions
Density 0.98 g/cm3
Solubility in water very soluble
Hazards
EU classification C, N [1]
R-phrases R21/22, R34, R50 [1]
S-phrases S36/37/39, S45, S61 [1]
NFPA 704
NFPA 704.svg
0
3
0
Flash point 250 °C (if solvent based)
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Benzalkonium chloride, also known as BZK, alkyldimethylbenzylammonium chloride and ADBAC, is a cationic surface-acting agent belonging to the quaternary ammonium group. It has three main categories of use: as a biocide, a cationic surfactant, and phase transfer agent in the chemical industry. The chemical is a nitrogenous mixture of alkylbenzyldimethylammonium chlorides of various even-numbered[2] alkyl chain lengths.