Benzoctamine

Title: Benzoctamine
CAS Registry Number: 17243-39-9
CAS Name: N-Methyl-9,10-ethanoanthracene-9(10H)-methanamine
Additional Names: 1-(methylaminomethyl)dibenzo[b,e]bicyclo[2.2.2]octadiene; 9-(methylaminomethyl)-9,10-dihydro-9,10-ethanoanthracene
Molecular Formula: C18H19N
Molecular Weight: 249.35
Percent Composition: C 86.70%, H 7.68%, N 5.62%
Literature References: Prepn: BE 610863; P. Schmidt et al., US 3399201 (1962, 1968 to Ciba); Wilhelm, Schmidt, Helv. Chim. Acta 52, 1385 (1969). Pharmacology: Keberle et al., Present Status Psychotropic Drugs (Excerpta Medica, New York, 1969) p 123; Baltzer, Bein, Arch. Int. Pharmacodyn. Ther. 201, 25 (1973). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
Derivative Type: Hydrochloride
CAS Registry Number: 10085-81-1
Manufacturers' Codes: Ba-30803
Trademarks: Tacitin (Novartis)
Molecular Formula: C18H19N.HCl
Molecular Weight: 285.81
Percent Composition: C 75.64%, H 7.05%, N 4.90%, Cl 12.40%
Properties: Crystals, mp 320-322°. pKa: 7.6. LD50 orally in rats: 700 ±170 mg/kg (Goldenthal).
Melting point: mp 320-322°
pKa: pKa: 7.6
Toxicity data: LD50 orally in rats: 700 ±170 mg/kg (Goldenthal)
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic.
Benzodepa Benzofuran Benzoguanamine Benzohydrol Benzoic Anhydride

Benzoctamine
Benzoctamine.svg
Systematic (IUPAC) name
N-methyl-9,10-ethanoanthracene-9(10H)-methanamine
Clinical data
Legal status  ?
Routes Intravenous, oral
Pharmacokinetic data
Metabolism Hepatic
Half-life 2 to 3 hours
Excretion Renal
Identifiers
CAS number 17243-09-9 YesY
ATC code N05BD01
PubChem CID 28425
ChemSpider 26444 YesY
UNII 734MM7Y191 YesY
Chemical data
Formula C18H19N 
Mol. mass 249.35 g/mol
 YesY (what is this?)  (verify)

Benzoctamine is a drug that possesses sedative and anxiolytic properties. It is different from most sedative drugs because in most clinical trials it does not produce respiratory depression, but actually stimulates the respiratory system. When co-administered with other drugs that cause respiratory depression, like morphine, it can cause increased respiratory depression. Peak effects are reached at about an hour, and effects wear off after about 2–3 hours. This drug is also used as a sedative in the hospital scene in patients who have respiratory failure.

It appears to reduce turnover of serotonin.[1]

Its effects can be variable.[2]