Bevantolol

Title: Bevantolol
CAS Registry Number: 59170-23-9
CAS Name: 1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol
Additional Names: 1-[(3,4-dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol
Molecular Formula: C20H27NO4
Molecular Weight: 345.43
Percent Composition: C 69.54%, H 7.88%, N 4.05%, O 18.53%
Literature References: Cardioselective b1-adrenergic blocker. Prepn: BE 790165; A. Holmes, R. F. Meyer, US 3857891 (1973, 1974 both to Parke, Davis & Co.); M. L. Hoefle et al., J. Med. Chem. 18, 148 (1975). Pharmacology in animals: S. G. Hastings et al., Arch. Int. Pharmacodyn. Ther. 226, 81 (1977). Cardiovascular effects in animals: I. D. Dukes, E. M. Vaughan Williams, Br. J. Pharmacol. 84, 365 (1985). Cardioselectivity in asthmatic patients: C.-G. Löfdahl et al., Pharmacotherapy 4, 205 (1984). GC determn in plasma: E. J. Randinitis et al., J. Chromatogr. 308, 345 (1984). Pharmacokinetics in humans: P. Vermeij, P. van Brummelen, Eur. J. Clin. Pharmacol. 30, 375 (1986). Comparative clinical trial with hydrochlorothiazide in hypertension: C. P. Lucas et al., Clin. Ther. 8, 49 (1985). Symposium on pharmacology and clinical efficacy: Am. J. Cardiol. 58, 1E-44E (1986).
Derivative Type: Hydrochloride
CAS Registry Number: 42864-78-8
Manufacturers' Codes: CI-775
Trademarks: Ranestol (Parke-Davis); Sentiloc (Benzon); Vantol (Parke-Davis)
Molecular Formula: C20H27NO4.HCl
Molecular Weight: 381.89
Percent Composition: C 62.90%, H 7.39%, N 3.67%, O 16.76%, Cl 9.28%
Properties: Crystals from acetonitrile, mp 137-138°.
Melting point: mp 137-138°
Therap-Cat: Antianginal; antihypertensive; antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives.
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Bevantolol
Bevantolol.png
Systematic (IUPAC) name
(RS)-[2-(3,4-dimethoxyphenyl)ethyl][2-hydroxy-3-(3-methylphenoxy)propyl]amine
Clinical data
AHFS/Drugs.com International Drug Names
Legal status Prescription only
Routes Oral
Identifiers
CAS number 59170-23-9 YesY
ATC code C07AB06
PubChem CID 2372
DrugBank DB01295
ChemSpider 2282 YesY
UNII 34ZXW6ZV21 YesY
ChEBI CHEBI:238698 YesY
ChEMBL CHEMBL314010 YesY
Chemical data
Formula C20H27NO4 
Mol. mass 345.43 g/mol
 YesY (what is this?)  (verify)

Bevantolol (INN) is a drug that acts as both a beta blocker and a calcium channel blocker.[1]