Bezafibrate

Title: Bezafibrate
CAS Registry Number: 41859-67-0
CAS Name: 2-[4-[2-[(4-Chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid
Additional Names: 2-[p-[2-(p-chlorobenzamido)ethyl]phenoxy]-2-methylpropionic acid; a-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyric acid
Manufacturers' Codes: BM-15075
Trademarks: Befizal (Oberval); Bezalip (Boehringer, Mann.); Bezatol (Kissei); Cedur (Boehringer, Mann.); Difaterol (Andreu)
Molecular Formula: C19H20ClNO4
Molecular Weight: 361.82
Percent Composition: C 63.07%, H 5.57%, Cl 9.80%, N 3.87%, O 17.69%
Literature References: Prepn: E. Witte et al., DE 2149070; eidem, US 3781328 (both 1973 to Boehringer, Mann.). Pharmacology: R. Zimmerman et al., Atherosclerosis 29, 477 (1978). Clinical studies: A. G. Olsson, P. D. Lang, ibid. 31, 421, 429 (1978); P. Wahl et al., Dtsch. Med. Wochenschr. 103, 1233 (1978). Review of pharmacodynamics and therapeutic use: J. P. Monk, P. A. Todd, Drugs 33, 539-576 (1987).
Properties: Crystals from acetone, mp 186°.
Melting point: mp 186°
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.
Bialamicol Biapenem Bibenzonium Bromide Bibenzyl Bibrocathol

Bezafibrate
Bezafibrate.svg
Systematic (IUPAC) name
2-(4-{2-[(4-chlorobenzoyl)amino]ethyl}phenoxy)-2-methylpropanoic acid
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a682711
Legal status POM (UK) -only (US)
Routes Oral
Identifiers
CAS number 41859-67-0 YesY
ATC code C10AB02
PubChem CID 39042
IUPHAR ligand 2668
DrugBank DB01393
ChemSpider 35728 YesY
UNII Y9449Q51XH YesY
KEGG D01366 YesY
ChEBI CHEBI:47612 YesY
ChEMBL CHEMBL264374 YesY
Chemical data
Formula C19H20ClNO4 
Mol. mass 361.819 g/mol
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Bezafibrate (marketed as Bezalip and various other brand names) is a fibrate drug used for the treatment of hyperlipidaemia. It helps to lower LDL cholesterol and triglyceride in the blood, and increase HDL.