Biapenem

Title: Biapenem
CAS Registry Number: 120410-24-4
CAS Name: 6-[[(4R,5S,6S)-2-Carboxy-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt
Additional Names: (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]-triazolium-6-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
Manufacturers' Codes: LJC-10627; L-627; CL-186815
Molecular Formula: C15H18N4O4S
Molecular Weight: 350.39
Percent Composition: C 51.42%, H 5.18%, N 15.99%, O 18.26%, S 9.15%
Literature References: 1-b-methyl-carbapenem antibiotic. Prepn: T. Kumagai et al., EP 289801; eidem, US 4990613 (1988, 1991 both to Lederle). Total synthesis: Y. Nagao et al., J. Org. Chem. 57, 4243 (1992). Renal dehydropeptidase stability: M. Hikida et al., Antimicrob. Agents Chemother. 36, 481 (1992). In-vitro antimicrobial spectrum: H. M. Wexler et al., J. Antimicrob. Chemother. 33, 629 (1994); H. Y. Chen, D. M. Livermore, ibid. 949. Clinical pharmacokinetics: M. Nakashima et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 31, 70 (1993). Clinical evaluation: H. Meguro et al., Jpn. J. Antibiot. 47, 903 (1994).
Properties: Amorphous, pale yellow powder from acetone/water, occurs as hemihydrate. [a]D20 -32.9° (c = 0.5).
Optical Rotation: [a]D20 -32.9° (c = 0.5)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Carbapenems.
Bibenzonium Bromide Bibenzyl Bibrocathol Bicalutamide Bicozamycin

Biapenem
Biapenem.png
Systematic (IUPAC) name
(4R,5S,6S)-3-(6,7-dihydro-5H- pyrazolo[1,2-a][1,2,4]triazol-8- ium-6-ylsulfanyl)- 6-(1-hydroxyethyl)- 4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2- ene-2-carboxylate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status Prescription only
Routes IV
Identifiers
CAS number 120410-24-4 YesY
ATC code J01DH05
PubChem CID 71339
ChemSpider 64442 YesY
UNII YR5U3L9ZH1 YesY
ChEBI CHEBI:3089 YesY
ChEMBL CHEMBL285347 YesY
Chemical data
Formula C15H18N4O4S 
Mol. mass 350.39 g/mol
 YesY (what is this?)  (verify)

Biapenem (INN) is a carbapenem antibiotic. It has in vitro activity against anaerobes.[1]

Approved in Japan in 2001.