Bifonazole

Title: Bifonazole
CAS Registry Number: 60628-96-8
CAS Name: 1-([1,1¢-Biphenyl]-4-ylphenylmethyl)-1H-imidazole
Additional Names: (±)-1-(p,a-diphenylbenzyl)imidazole
Manufacturers' Codes: Bay h 4502
Trademarks: Amycor (Lipha); Azolmen (Menarini); Bedriol (Andromaco); Mycospor (Bayer); Mycosporan (Bayer)
Molecular Formula: C22H18N2
Molecular Weight: 310.39
Percent Composition: C 85.13%, H 5.85%, N 9.03%
Literature References: Antimycotic deriv of imidazole. Prepn: E. Regel et al., DE 2461406; eidem, US 4118487 (1976, 1978 both to Bayer). Series of articles on in vitro and in vivo antimycotic efficacy, microscopic studies, pharmacokinetics, efficacy in dermatomycoses and comparison with clotrimazole and miconazole, q.q.v.: Arzneim.-Forsch. 33, 517-551, 745-754 (1983). Toxicology: G. Schlüter, ibid. 739.
Properties: Crystals from acetonitrile, mp 142°. Very lipophilic. Sol in alcohols, DMF, DMSO. Soly in water at pH 6: <0.1 mg/100 ml. Stable in aq soln at pH 1-12. LD50 in male mice, rats (mg/kg): 2629, 2854 orally (Schlüter).
Melting point: mp 142°
Toxicity data: LD50 in male mice, rats (mg/kg): 2629, 2854 orally (Schlüter)
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Imidazoles.
BIGCHAP Biguanide Bikhaconitine Bilberry Bilirubin

Bifonazole
Bifonazole.svg
Systematic (IUPAC) name
(RS)-1-[phenyl(4-phenylphenyl)methyl]-1H-imidazole
Clinical data
AHFS/Drugs.com International Drug Names
Legal status OTC (US)
Routes topic
Identifiers
CAS number 60628-96-8 YesY
ATC code D01AC10
PubChem CID 2378
DrugBank DB04794
ChemSpider 2287 YesY
UNII QYJ305Z91O YesY
KEGG D01775 YesY
ChEMBL CHEMBL277535 YesY
Chemical data
Formula C22H18N2 
Mol. mass 310.392 g/mol
 YesY (what is this?)  (verify)

Bifonazole is an imidazole antifungal drug. Bifonazole is marketed by Bayer under the trade mark CANESPOR in ointment form.