Title: Biotin l-Sulfoxide
CAS Registry Number: 3376-83-8
CAS Name: [3aS-(3aa,4b,5b,6aa)]-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid 5-oxide
Additional Names: AN factor
Molecular Formula: C10H16N2O4S
Molecular Weight: 260.31
Percent Composition: C 46.14%, H 6.20%, N 10.76%, O 24.59%, S 12.32%
Literature References: Isolated from Aspergillus niger culture filtrate where growth had taken place in the presence of pimelic acid; also from milk residue concentrates or by synthesis: Melville, J. Biol. Chem. 208, 495 (1954); Wright et al., J. Am. Chem. Soc. 76, 4163 (1954).
Properties: Polymorphic plates from water, mp 238° (some dec). [a]D20 -39.5° (c = 1.01 in 0.1N NaOH). Ineffective in curing the biotin deficiency syndrome when administered to rats at a level 100 times the effective dose of biotin.
Melting point: mp 238° (some dec)
Optical Rotation: [a]D20 -39.5° (c = 1.01 in 0.1N NaOH)