Biricodar

Title: Biricodar
CAS Registry Number: 159997-94-1
CAS Name: (2S)-1-[Oxo(3,4,5-trimethoxyphenyl)acetyl]-2-piperidinecarboxylic acid 4-(3-pyridinyl)-1-[3-(3-pyridinyl)propyl]butyl ester
Molecular Formula: C34H41N3O7
Molecular Weight: 603.71
Percent Composition: C 67.64%, H 6.85%, N 6.96%, O 18.55%
Literature References: Chemosensitizer that restores sensitivity to cytotoxic agents in multidrug resistant (MDR) cells. Prepn: D. M. Armistead et al., WO 9407858; eidem, US 5620971 (1994, 1997 both to Vertex). Effect on MDR mediated by P-glycoprotein: U. A. Germann et al., Anti-Cancer Drugs 8, 125 (1997); by multidrug resistance-associated protein (MRP): eidem, ibid. 141. Clinical pharmacology, pharmacokinetics: E. K. Rowinsky et al., J. Clin. Oncol. 16, 2964 (1998).
Derivative Type: Dicitrate
CAS Registry Number: 174254-13-8
Manufacturers' Codes: VX-710
Trademarks: Incel (Vertex)
Molecular Formula: C34H41N3O7.2C6H8O7
Molecular Weight: 987.95
Percent Composition: C 55.92%, H 5.82%, N 4.25%, O 34.01%
Properties: Sol in water.
Therap-Cat: Antineoplastic adjunct (chemosensitizer).
Keywords: Antineoplastic Adjunct; Chemosensitizer.
Bis(1,2-dimethylpropyl)borane Bis(1-methylamyl) Sodium Sulfosuccinate Bis(1-naphthylmethyl)amine Bis(2-ethylhexyl) Sebacate Bis(2-mercaptoethyl)sulfone

Biricodar
Biricodar.svg
Systematic (IUPAC) name
1,7-di(pyridin-3-yl)heptan-4-yl (2S)-1-[oxo(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate
Clinical data
Legal status  ?
Identifiers
CAS number 174254-13-8
ATC code None
PubChem CID 3037617
ChemSpider 2301309 YesY
UNII 9WQP0L619L YesY
ChEMBL CHEMBL350775 YesY
Chemical data
Formula C34H41N3O7 
Mol. mass 603.705 g/mol
 YesY (what is this?)  (verify)

Biricodar (INN, codename VX-710, marketed as the dicitrate salt under the trade name Incel) is a pharmaceutical drug released by Vertex Pharmaceuticals in 1999 to help treat ovarian cancer patients.