Title: Bombesin
CAS Registry Number: 31362-50-2
CAS Name: 2-L-Glutamine-6-L-asparaginealytesin
Molecular Formula: C71H110N24O18S
Molecular Weight: 1619.85
Percent Composition: C 52.64%, H 6.84%, N 20.75%, O 17.78%, S 1.98%
Literature References: Pharmacologically active tetradecapeptide found in skins of European amphibians of the family Discoglossidae, principally Bombina bombina and Bombina variegata variegata. Isoln and structure: A. Anastasi et al., Experientia 27, 166 (1971). Pharmacological activity: V. Erspamer et al., J. Pharm. Pharmacol. 22, 875 (1970). Synthesis: L. Bernardi et al., Experientia 27, 873 (1971). It is a potent stimulant of gastric and pancreatic secretions in mammals; a bombesin-like immunoreactive peptide is found in both brain and gut, cf. J. M. Polak et al., Lancet 1, 1109 (1976). Other actions include hypertensive reactions, antidiuresis, and hyperglycemic activity. Bombesin has been shown to have a strong effect on core temperature lowering in rats: M. Brown et al., Science 196, 996 (1977). High levels of intracellular bombesin have also been found in human small-cell lung carcinoma: T. W. Moody et al., ibid. 214, 1246 (1981). Brief review of chemistry, isoln, purification: V. Mutt, Biochem. Soc. Trans. 8, 11 (1980). Effect on suppression of food intake: J. Gibbs et al., Nature 282, 208 (1979). Pharmacological reviews: G. Bertaccini, Pharmacol. Rev. 28, 127 (1976); S. R. Bloom, J. M. Polak, Adv. Clin. Chem. 21, 177 (1980).
Derivative Type: Hydrochloride
Molecular Formula: C71H112Cl2N24O18S
Molecular Weight: 1692.77
Percent Composition: C 50.38%, H 6.67%, Cl 4.19%, N 19.86%, O 17.01%, S 1.89%
Properties: Cryst from 99% ethanol, mp 185° (dec). [a]D24 -20.6° (c = 0.65 in DMF-HMPT 8:2).
Melting point: mp 185° (dec)
Optical Rotation: [a]D24 -20.6° (c = 0.65 in DMF-HMPT 8:2)
Bomyl? Bone Morphogenetic Proteins Bongkrekic Acid Bopindolol Borazine

Bombesin full.png
CAS number 31362-50-2 N
PubChem 16133891
ChemSpider 26286924 YesY
IUPHAR ligand 616
Jmol-3D images Image 1
Molecular formula C71H110N24O18S
Molar mass 1619.85
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Bombesin is a 14-amino acid peptide[1] originally isolated from the skin of the European fire-bellied toad (Bombina bombina).[2] It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3.[3] It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.[4]

Bombesin is also a tumor marker for small cell carcinoma of lung, gastric cancer, and neuroblastoma.[5]