Brimonidine

Title: Brimonidine
CAS Registry Number: 59803-98-4
CAS Name: 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine
Additional Names: 5-bromo-6-(2-imidazolin-2-ylamino)quinoxaline
Manufacturers' Codes: UK-14304; AGN-190342
Molecular Formula: C11H10BrN5
Molecular Weight: 292.13
Percent Composition: C 45.23%, H 3.45%, Br 27.35%, N 23.97%
Literature References: a2-Adrenoceptor agonist. Prepn: J. C. Danielewicz et al., DE 2309160; eidem, US 3890319 (1973, 1975 both to Pfizer). HPLC determn in serum and aqueous humour of the eye: N. K. Karamanos et al., Biomed. Chromatogr. 13, 86 (1999). Clinical study in control of intraocular pressure: R. David et al., Arch. Ophthalmol. 111, 1387 (1993); L. J. Katz et al., Am. J. Ophthalmol. 127, 20 (1999). Review of pharmacology and mechanisms of action: J. C. Adkins, J. A. Balfour, Drugs Aging 12, 225-241 (1998); of pharmacotherapeutic profile: L. B. Cantor, Expert Opin. Pharmacother. 1, 815-834 (2000).
Properties: Yellow crystals from ethanol, mp 252°.
Melting point: mp 252°
Derivative Type: D-Tartrate
CAS Registry Number: 70359-46-5
Manufacturers' Codes: UK-14304-18; AGN-190342-LF
Trademarks: Alphagan (Allergan)
Molecular Formula: C11H10BrN5.C4H6O6
Molecular Weight: 442.22
Percent Composition: C 40.74%, H 3.65%, Br 18.07%, N 15.84%, O 21.71%
Properties: White crystals from acetone, mp 207.5°.
Melting point: mp 207.5°
Therap-Cat: Antiglaucoma.
Keywords: Antiglaucoma.
Brinzolamide Brivaracetam Brivudine Brodimoprim Bromacil

Brimonidine
Brimonidine structure.png
Systematic (IUPAC) name
5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl) quinoxalin-6-amine
Clinical data
Trade names Alphagan, Mirvaso
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a601232
Pregnancy cat. B (US)
Legal status -only (US)
Routes Ocular, 1 drop
Pharmacokinetic data
Metabolism Primarily liver
Half-life 3 hours
Identifiers
CAS number 59803-98-4 YesY
ATC code D11AX21 S01EA05
PubChem CID 2435
IUPHAR ligand 520
DrugBank DB00484
ChemSpider 2341 YesY
UNII E6GNX3HHTE YesY
KEGG D07540 YesY
ChEBI CHEBI:3175 YesY
ChEMBL CHEMBL844 YesY
Chemical data
Formula C11H10BrN5 
Mol. mass 292.135 g/mol
 YesY (what is this?)  (verify)

Brimonidine (bri-MOE-ni-deen) is a drug used under the brand names Alphagan and Alphagan-P to treat open-angle glaucoma or ocular hypertension, and as Mirvaso for facial erythema or rosacea.

It acts via decreasing synthesis of aqueous humor, and increasing the amount that drains from the eye through uveoscleral outflow. As a treatment for glaucoma, it is usually given in eyedrop form.