Bromazepam

Title: Bromazepam
CAS Registry Number: 1812-30-2
CAS Name: 7-Bromo-1,3-dihydro-5-(2-pyridinyl)-2H-1,4-benzodiazepin-2-one
Additional Names: 7-bromo-5-(2-pyridyl)-3H-1,4-benzodiazepin-2(1H)-one
Manufacturers' Codes: Ro-5-3350
Trademarks: Compendium (Polifarma); Creosedin (Osiris); Durazanil (Durachemie); Lectopam (Roche); Lexomil (Roche); Lexotan (Roche); Lexotanil (Roche); Normoc (Merckle)
Molecular Formula: C14H10BrN3O
Molecular Weight: 316.15
Percent Composition: C 53.19%, H 3.19%, Br 25.27%, N 13.29%, O 5.06%
Literature References: Prepn: Berger et al., BE 619101; eidem, Fryer et al., US 3100770 (1962, 1963 to Hoffmann-La Roche); eidem, J. Pharm. Sci. 53, 264 (1964); US 3182065; US 3182067 (both 1965 to Hoffmann-La Roche). Pharmacology: Korol, Brown, Pharmacology 1, 115 (1968). Metabolism: M. A. Schwartz et al., J. Pharm. Sci. 62, 1776 (1973); Drug Metab. Dispos. 2, 31 (1974). Evaluation as pre-anesthesia medication: P. Chalmers, J. N. Horton, Anesthesia 39, 370 (1984). Multicenter clinical comparison with lorazepam, q.v.: G. J. Cordingley et al., Curr. Med. Res. Opin. 9, 505 (1985). Evaluation of adverse effects and withdrawal reactions: R. Fontaine et al., Psychopharmacol. Bull. 21, 91 (l985). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Comprehensive description: M. M. Hassan, M. A. Abounassif, Anal. Profiles Drug Subs. 16, 1-51 (1987).
Properties: Colorless prisms from acetone, mp 237-238.5° (dec). LD50 orally in rats: 3050 ±405 mg/kg (Goldenthal).
Melting point: mp 237-238.5° (dec)
Toxicity data: LD50 orally in rats: 3050 ±405 mg/kg (Goldenthal)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives.
Bromcresol Green Bromcresol Purple Bromelain Bromfenac Bromhexine

Bromazepam
Bromazepam.svg
Bromazepam-from-xtal-3D-balls.png
Systematic (IUPAC) name
9-Bromo-6-pyridin-2-yl-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
Clinical data
Trade names Lexotan, Lexotanil
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat. D (USA)
Legal status Schedule IV(US)
Routes Oral
Pharmacokinetic data
Bioavailability 84%
Metabolism Hepatic
Half-life 12-20 hours
Excretion Renal
Identifiers
CAS number 1812-30-2 YesY
ATC code N05BA08
PubChem CID 2441
DrugBank DB01558
ChemSpider 2347 YesY
UNII X015L14V0O YesY
KEGG D01245 YesY
ChEMBL CHEMBL277062 YesY
Chemical data
Formula C14H10BrN3O 
Mol. mass 316.2
 YesY (what is this?)  (verify)

Bromazepam (marketed under several brand names, including Lectopam, Lexotan, Lexilium, Lexaurin, Brazepam, Rekotnil, Bromaze and Lexotanil)[1] is a benzodiazepine derivative drug, patented by Roche in 1963[2] and developed clinically in the 1970s.[3][4] It has mainly anxiolytic properties and at higher doses of 12 milligrams or more also shows sedative, hypnotic and skeletal muscle relaxant properties.[5]