Title: Bromodichloromethane
CAS Registry Number: 75-27-4
Additional Names: Dichlorobromomethane; BDCM
Manufacturers' Codes: NCI-C55243
Molecular Formula: CHBrCl2
Molecular Weight: 163.83
Percent Composition: C 7.33%, H 0.62%, Br 48.77%, Cl 43.28%
Literature References: Trihalomethane contaminant found in chlorinated water. Prepn: O. Jacobsen, R. Neumeister, Ber. 15, 599 (1882); M. Fedorynski et al., Synth. Commun. 7, 287 (1977). Disposition and metabolism: J. M. Mathews et al., J. Toxicol. Environ. Health 30, 15 (1990). Toxicity studies: F. J. Bowman et al., Toxicol. Appl. Pharmacol. 44, 213 (1978); Y. Aida et al., J. Toxicol. Sci. 17, 51 (1992). Review of quantitative analyses, toxicity and carcinogenicity: IARC Monographs 52, 179-212 (1991); of toxicology and human exposure: Toxicological Profile for Bromodichloromethane (PB90-167461, 1989) 89 pp.
Properties: Colorless liquid. bp 88.4-88.6° (Fedorynski); also reported as bp 91-92° (Jacobsen). d15 1.9254. nD20 1.4967. LD50 in male, female mice (mg/kg): 450, 900 orally (Bowman).
Boiling point: bp 88.4-88.6° (Fedorynski); bp 91-92° (Jacobsen)
Index of refraction: nD20 1.4967
Density: d15 1.9254
Toxicity data: LD50 in male, female mice (mg/kg): 450, 900 orally (Bowman)
CAUTION: Potential symptoms of acute oral overexposure in animals are liver and kidney damage; CNS depression, incoordination, sleepiness, lethargy, sedation. Chronic exposure has been associated with cancer of liver, kidney and intestines. See: Toxicological Profile for Bromodichloromethane (PB90-167461, 1989) 77 pp. This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-35.
Use: Chemical reagent, intermediate in organic synthesis.
Bromodiphenhydramine Bromofenofos Bromoform Bromolysergide Bromophenol

Bromodichloromethane displayed.svg
CAS number 75-27-4 YesY
PubChem 6359
ChemSpider 6119 YesY
EC number 200-856-7
KEGG C14708 YesY
ChEBI CHEBI:34591 YesY
RTECS number PA5310000
Jmol-3D images Image 1
Molecular formula CHBrCl2
Molar mass 163.8 g/mol
Appearance Colorless liquid
Density 1.980 g/cm3
Melting point -57 °C
Boiling point 90 °C
Solubility in water 4.5 g/l at 20 °C
R-phrases R45 R46 R20/21/22 R36/37/38
S-phrases S45 S26 S28 S27 S36/37/39
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Bromodichloromethane is a trihalomethane with formula CHBrCl2.

It has been formerly used as a flame retardant, solvent for fats and waxes and because of its high density for mineral separation. Now it is only used as a reagent or intermediate in organic chemistry.

It can also occur in municipally-treated drinking water as a by-product of the chlorine disinfection process.[1]