Title: Bromoform
CAS Registry Number: 75-25-2
CAS Name: Tribromomethane
Molecular Formula: CHBr3
Molecular Weight: 252.73
Percent Composition: C 4.75%, H 0.40%, Br 94.85%
Literature References: Prepd from acetone and sodium hypobromite: Günther, Jahresber. Fortschr. Chem. 1887, 741 (Beilstein vol. 1, 68); Kergomard, Bull. Soc. Chim. Fr. 1961, 2360. Toxicity data: Kutob, Plaa, Toxicol. Appl. Pharmacol. 4, 354 (1962). Review of toxicology and human exposure: Toxicological Profile for Bromoform and Dibromochloromethane (PB2006-100001, 2005) 273 pp.
Properties: Heavy liquid; chloroform odor; sweetish taste. bp 149-150°. mp 7.5°. d415 2.9035. nD15 1.6005. Sol in about 800 parts water; miscible with alc, benzene, chloroform, ether, petr ether, acetone, oils. Gradually dec, acquiring a yellow color; air and light accelerate the decompn. May be preserved by the addition of 3-4% alc. d 2.6-2.7. Keep in well-closed containers, protected from light. Incompat. Caustic alkalies. LD50 s.c. in mice: 7.2 mmol/kg (Kutob, Plaa).
Melting point: mp 7.5°
Boiling point: bp 149-150°
Index of refraction: nD15 1.6005
Density: d415 2.9035; d 2.6-2.7
Toxicity data: LD50 s.c. in mice: 7.2 mmol/kg (Kutob, Plaa)
CAUTION: Potential symptoms of overexposure are irritation of skin, eyes and respiratory system; CNS depression; liver, kidney damage. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 34.
Use: In separating mixtures of minerals.
Therap-Cat: Has been used as sedative, hypnotic; antitussive.
Keywords: Antitussive; Sedative/Hypnotic.
Bromolysergide Bromophenol Bromophos Bromopride Bromosalicylchloranilide

Skeletal formula of bromoform Stereo, skeletal formula of bromoform with the explicit hydrogen added
Spacefill model of bromoform
  • R-20B3[citation needed]
  • UN 2515[citation needed]
CAS number 75-25-2 YesY
PubChem 5558
ChemSpider 13838404 YesY
EC number 200-854-6
UN number 2515
DrugBank DB03054
KEGG C14707 YesY
MeSH bromoform
ChEBI CHEBI:38682 YesY
RTECS number PB5600000
Beilstein Reference 1731048
Gmelin Reference 49500
Jmol-3D images Image 1
Molecular formula CHBr3
Molar mass 252.73 g mol−1
Appearance Colorless liquid
Density 2.89 g mL−1
Melting point −4 to 16 °C; 25 to 61 °F; 269 to 289 K
Boiling point 147 to 151 °C; 296 to 304 °F; 420 to 424 K
Solubility in water 3.2 g L−1 (at 30 °C)
log P 2.435
Vapor pressure 670 Pa (at 20.0 °C)
kH 17 μmol Pa−1 kg−1
Refractive index (nD) 1.595
heat capacity C
130.5 J K−1 mol−1
Std enthalpy of
formation ΔfHo298
6.1–12.7 kJ mol−1
Std enthalpy of
combustion ΔcHo298
−549.1–−542.5 kJ mol−1
MSDS External MSDS
GHS pictograms The skull-and-crossbones pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) The environment pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
GHS signal word DANGER
GHS hazard statements H302, H315, H319, H331, H411
GHS precautionary statements P261, P273, P305+351+338, P311
EU Index 602-007-00-X
EU classification Toxic T Dangerous for the Environment (Nature) N
R-phrases R22, R23, R36/38, R51/53
S-phrases (S1/2), S45, S63
NFPA 704
NFPA 704.svg
LD50 933.0 mg kg−1 (oral, rat)
Related compounds
Related alkanes
  • Dibromomethane
  • Tetrabromomethane
  • 1,1-Dibromoethane
  • 1,2-Dibromoethane
  • Tetrabromoethane
Supplementary data page
Structure and
n, εr, etc.
Phase behaviour
Solid, liquid, gas
Spectral data UV, IR, NMR, MS
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Bromoform (CHBr3) is a brominated organic solvent, pale yellow liquid at room temperature, with a high refractive index, very high density, and sweet odor is similar to that of chloroform. It is a trihalomethane, and is one of the four haloforms, the others being fluoroform, chloroform, and iodoform. Bromoform can be prepared by the haloform reaction using acetone and sodium hypobromite, by the electrolysis of potassium bromide in ethanol, or by treating chloroform with aluminum bromide. Currently its main use is as a laboratory reagent.

A bottle of bromoform with some in the adjacent beaker