Title: Bromopride
CAS Registry Number: 4093-35-0
CAS Name: 4-Amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
Additional Names: 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-o-anisamide
Trademarks: Emepride (Roche); Emoril (Roemmers); Viadil (Pharma Investi)
Molecular Formula: C14H22BrN3O2
Molecular Weight: 344.25
Percent Composition: C 48.85%, H 6.44%, Br 23.21%, N 12.21%, O 9.30%
Literature References: Prepn: M. L. Thominet, BE 620543; idem, US 3177252 (1962, 1965 both to Soc. d'Etudes Sci. Ind. de l'Ile-de-France); H. Mori, K. Shibata, DE 2119724 (1971 to Teikoku Hormone Manuf. Co.), C.A. 76, 99375e (1972). Action on guinea-pig ileum: J. Fontaine, J. J. Reuse, Arch. Int. Pharmacodyn. Ther. 213, 322 (1975). Effects on intestinal peristalsis in dogs: P. Sava et al., Arzneim.-Forsch. 29, 799 (1979). Clinical study: M. Fischer et al., Fortschr. Med. 97, 883 (1979). Pharmacokinetics: P. W. Lücker et al., Arzneim.-Forsch. 33, 453 (1983).
Derivative Type: Hydrochloride
CAS Registry Number: 52423-56-0
Trademarks: Cascapride (Cascan); Plesium (Chiesi); Praiden (Italchemie); Valopride (Vita); Viaben (Schrholz)
Molecular Formula: C14H22BrN3O2.HCl
Molecular Weight: 380.71
Percent Composition: C 44.17%, H 6.09%, Br 20.99%, N 11.04%, O 8.41%, Cl 9.31%
Derivative Type: Dihydrochloride monohydrate
Trademarks: Opridan (Locatelli)
Molecular Formula: C14H22BrN3O2.2HCl.H2O
Molecular Weight: 435.18
Percent Composition: C 38.64%, H 6.02%, Br 18.36%, N 9.66%, O 11.03%, Cl 16.29%
Therap-Cat: Antiemetic.
Keywords: Antiemetic.
Bromosalicylchloranilide Bromosaligenin Bromosuccinic Acid Bromotoluene Bromoxynil

Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
Legal status Prescription only
Routes Oral, IM, IV
Pharmacokinetic data
Bioavailability 50 to 75% (oral)
78% (intramuscular)
Protein binding 40%
Metabolism Hepatic
Half-life 4 to 5 hours
Excretion Renal, 10 to 14% unchanged
CAS number 4093-35-0 N
ATC code A03FA04
PubChem CID 2446
ChemSpider 2352 YesY
UNII 75473V2YZK YesY
KEGG D07101 YesY
Chemical data
Formula C14H22BrN3O2 
Mol. mass 344.248 g/mol
 N (what is this?)  (verify)

Bromopride (INN) is a dopamine antagonist with prokinetic properties widely used as an antiemetic, closely related to metoclopramide. It is not available in the United States.

Bromopride appears to be safe and effective for use in pregnancy.[1]