Title: Buclizine
CAS Registry Number: 82-95-1
CAS Name: 1-[(4-Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]piperazine
Additional Names: 1-(p-tert-butylbenzyl)-4-(p-chloro-a-phenylbenzyl)piperazine; 1-(p-chlorobenzhydryl)-4-(p-tert-butylbenzyl)diethylenediamine; 1-(p-tert-butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine; histabutyzine; histabutizine
Molecular Formula: C28H33ClN2
Molecular Weight: 433.03
Percent Composition: C 77.66%, H 7.68%, Cl 8.19%, N 6.47%
Literature References: Prepn: Morren, US 2709169 (1955 to U.C.B.), see also DE 964040, Lui et al., C.A. 62, 2776a (1965). Clinical evaluation as antiemetic in migraine: P. B. Jorgensen et al., Curr. Ther. Res. 16, 1276 (1974); E. I. Adam, J. Int. Med. Res. 15, 71 (1987).
Properties: bp0.001 217-220°.
Boiling point: bp0.001 217-220°
Derivative Type: Dihydrochloride
CAS Registry Number: 129-74-8
Manufacturers' Codes: UCB-4445
Trademarks: Aphilan (UCB); Buclina (Sanofi-Synthelabo); Longifene (UCB); Postafen (UCB)
Molecular Formula: C28H33ClN2.2HCl
Molecular Weight: 505.95
Percent Composition: C 66.47%, H 6.97%, Cl 21.02%, N 5.54%
Properties: mp 230-240°.
Melting point: mp 230-240°
Therap-Cat: Antiemetic.
Keywords: Antiemetic.
Buclosamide Bucloxic Acid Bucolome Bucumolol Budipine

Systematic (IUPAC) name
(RS)-1-[(4-chlorophenyl)- phenyl-methyl]-4- [(4-tert-butylphenyl) methyl] piperazine
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Legal status  ?
CAS number 82-95-1 YesY
ATC code R06AE01
PubChem CID 6729
DrugBank DB00354
ChemSpider 6473 YesY
UNII 0C94V6X681 YesY
Chemical data
Formula C28H33ClN2 
Mol. mass 433.028 g/mol
 N (what is this?)  (verify)

Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.[1]

In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare at migraine sufferers.[2]