Budipine

Title: Budipine
CAS Registry Number: 57982-78-2
CAS Name: 1-(1,1-Dimethylethyl)-4,4-diphenylpiperidine
Additional Names: 1-tert-butyl-4,4-diphenylpiperidine
Molecular Formula: C21H27N
Molecular Weight: 293.45
Percent Composition: C 85.95%, H 9.27%, N 4.77%
Literature References: Centrally acting deriv of diphenylpiperidine. Prepn: H. G. Menge, J. Klosa, DE 1936452; eidem, US 4016280 (1969, 1977 both to Byk Gulden). Pharmacological studies: U. Brand, H. G. Menge, Arzneim.-Forsch. 30, 1242 (1980); M. Eltze, ibid. 1129; H. G. Menge, U. Brand, ibid. 32, 85 (1982). Comparison to other drugs in treatment of dyskinesias: J. Siegfried, Can. J. Neurol. Sci. 6, 89 (1979). Clinical evaluation with levodopa in Parkinson's disease: K. Jellinger, H. Bliesath, J. Neurol. 234, 280 (1987).
Derivative Type: Hydrochloride
CAS Registry Number: 63661-61-0
Trademarks: Parkinsan (Byk Gulden)
Molecular Formula: C21H27N.HCl
Molecular Weight: 329.91
Percent Composition: C 76.45%, H 8.55%, N 4.25%, Cl 10.75%
Properties: LD50 in male mice, rats (mg/kg): 120, 165 orally; 33, 28 i.v. (Menge, Brand).
Toxicity data: LD50 in male mice, rats (mg/kg): 120, 165 orally; 33, 28 i.v. (Menge, Brand)
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian.
Budralazine Bufalin Bufencarb Bufeniode Bufetolol

Budipine
Budipine.svg
Systematic (IUPAC) name
1-tert-butyl-4,4-diphenylpiperidine[1]
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Identifiers
CAS number 57982-78-2 YesY
ATC code N04BX03
PubChem CID 68778
ChemSpider 62021 YesY
UNII L9026OPI2Z YesY
KEGG D07306 YesY
ChEMBL CHEMBL334491 YesY
Chemical data
Formula C21H27N 
Mol. mass 293.446 g/mol
 YesY (what is this?)  (verify)

Budipine is an antiparkinson agent.

Its mechanism of action is not well characterized.[2] It is believed to be an NMDA receptor antagonist,[3] however, promoting the synthesis of dopamine.[4]

Because it provides additional benefits relative to existing treatments, it probably does not precisely mimic the mechanism of an existing known treatment.[5]