Buformin

Title: Buformin
CAS Registry Number: 692-13-7
CAS Name: N-Butylimidodicarbonimidic diamide
Additional Names: 1-butylbiguanide; n-butylbiguanide; butyldiguanide; butformin
Manufacturers' Codes: W-37
Molecular Formula: C6H15N5
Molecular Weight: 157.22
Percent Composition: C 45.84%, H 9.62%, N 44.54%
Literature References: Prepn: Shapiro et al., J. Am. Chem. Soc. 81, 3728 (1959); Shapiro, Freedman, US 2961377 (1960 to USV). Toxicity study: Rikimaru et al., J. Antibiot. 18A, 196 (1965).
Properties: Strong base. Very sol in water.
Derivative Type: Hydrochloride
CAS Registry Number: 1190-53-0
Trademarks: Andere (Toyama); Biforon (Meiji); Bigunal (Nikken); Bufonamin (Kaken); Bulbonin (Sankyo); Diabrin (USV); Dibetos (Kodama); Gliporal (Grossmann); Insulamin (Iwaki); Krebon; Panformin (Shionogi); Silubin; Sindiatil; Tidemol (Roche); Ziavetine
Molecular Formula: C6H15N5.HCl
Molecular Weight: 193.68
Percent Composition: C 37.21%, H 8.33%, N 36.16%, Cl 18.30%
Properties: Crystals, mp 174-177°. Freely sol in water, alcohol. LD50 i.p. in mice: 380 mg/kg (Rikimaru).
Melting point: mp 174-177°
Toxicity data: LD50 i.p. in mice: 380 mg/kg (Rikimaru)
Derivative Type: Nitrate
Molecular Formula: C6H15N5.HNO3
Molecular Weight: 220.23
Percent Composition: C 32.72%, H 7.32%, N 38.16%, O 21.79%
Properties: Crystals from ethanol, dec 125-126°.
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Biguanides.
Bufotalin Bufotenine Bufotoxin Bufuralol Bulan?

Buformin
Skeletal formula of buformin
Skeletal formula of buformin
Identifiers
CAS number 692-13-7 YesY
PubChem 2468
ChemSpider 2374 YesY
UNII W2115E9C7B YesY
EC number 211-726-4
DrugBank DB04830
KEGG D00595 YesY
MeSH Buformin
ChEMBL CHEMBL39736 YesY
ATC code A10BA03
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C6H15N5
Molar mass 157.22 g mol−1
log P -1.2[1]
Pharmacology
Routes of
administration
Oral
Excretion Renal
Related compounds
Related compounds
  • Carmustine
  • Methylarginine
  • Asymmetric dimethylarginine
  • Acecarbromal
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed by German pharmaceutical company Grünenthal as Silubin.