Butedronic Acid

Title: Butedronic Acid
CAS Registry Number: 51395-42-7
CAS Name: (Diphosphonomethyl)butanedioic acid
Additional Names: (diphosphonomethyl)succinic acid; 2,3-dicarboxypropane-1,1-diphosphonic acid; DPD
Molecular Formula: C5H10O10P2
Molecular Weight: 292.07
Percent Composition: C 20.56%, H 3.45%, O 54.78%, P 21.21%
Literature References: Prepn: A. Heins et al., DE 2217692 (1973 to Henkel); eidem, US 3923876 (1975 to Bayer A.G.); K. H. Worms, H. Blum, Z. Anorg. Allg. Chem. 457, 219 (1979); and physical-chemical properties: N. Vanlic-Razumenic et al., J. Serb. Chem. Soc. 51, 63 (1986). Clinical pharmacokinetics of 99mTc complex: C. Schümichen, H. Schmidt, Nuklearmedizin Suppl. 19, 930 (1982). Clinical evaluation of 99mTc complex as skeletal imaging agent: G. Godart et al., Clin. Nucl. Med. 11, 92 (1986).
Derivative Type: Monohydrate
Properties: White crystalline powder from glacial acetic acid and water (15:1), mp 150°. uv max (water): 208 nm (e 274).
Melting point: mp 150°
Absorption maximum: uv max (water): 208 nm (e 274)
Derivative Type: Tetrasodium salt
CAS Registry Number: 97772-98-0
Manufacturers' Codes: Tc-924 (DPD)
Trademarks: Teceos (Hoechst Roussel)
Molecular Formula: C5H6Na4O10P2
Molecular Weight: 380.00
Percent Composition: C 15.80%, H 1.59%, Na 24.20%, O 42.10%, P 16.30%
Therap-Cat: 99mTc complex as diagnostic aid (radioactive imaging agent).
Butethal Butethamate Butethamine Buthalital Sodium Buthiazide