Butibufen

Title: Butibufen
CAS Registry Number: 55837-18-8
CAS Name: a-Ethyl-4-(2-methylpropyl)benzeneacetic acid
Additional Names: 2-(4-isobutylphenyl)butyric acid
Trademarks: Butilopan (Juste)
Molecular Formula: C14H20O2
Molecular Weight: 220.31
Percent Composition: C 76.32%, H 9.15%, O 14.52%
Literature References: Prepn: L. Aparicio et al., DE 2505813; eidem, US 4031243 (1976, 1977 both to Juste); J. M. Carretero et al., Eur. J. Med. Chem. 13, 77 (1978). Pharmacology: L. Aparicio, Arch. Int. Pharmacodyn. Ther. 227, 130 (1977). Pharmacokinetics: R. Revilla De Granda et al., An. R. Acad. Farm. 43, 419 (1977), C.A. 88, 83349 (1978). HPLC determination: L. González Tavares et al., Arzneim.-Forsch. 42, 818 (1992).
Properties: Solid, mp 51-53°. LD50 orally in mice: 810 mg/kg (Carretero).
Melting point: mp 51-53°
Toxicity data: LD50 orally in mice: 810 mg/kg (Carretero)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylbutyric Acid Derivatives.
Butidrine Hydrochloride Butirosin Butobendine Butoconazole Butoctamide