Title: Butoconazole
CAS Registry Number: 64872-76-0
CAS Name: 1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole
Molecular Formula: C19H17Cl3N2S
Molecular Weight: 411.78
Percent Composition: C 55.42%, H 4.16%, Cl 25.83%, N 6.80%, S 7.79%
Literature References: Imidazole derivative with antifungal properties. Prepn: K. A. M. Walker, US 4078071 (1978 to Syntex). Prepn, toxicity, activity vs Candida albicans in mice: K. A. M. Walker et al., J. Med. Chem. 21, 840 (1978). In vitro comparison with other antifungal agents: F. C. Odds et al., J. Antimicrob. Chemother. 14, 105 (1984). Clinical trials in treatment of vulvovaginal candidiasis: W. Droegemueller et al., Obstet. Gynecol. 64, 530 (1984); J. B. Jacobson et al., Acta Obstet. Gynecol. Scand. 64, 241 (1985). Comparison with miconazole, q.v.: C. S. Bradbeer et al., Genitourin. Med. 61, 270 (1985).
Properties: Crystals from cyclohexane, mp 68-70.5°.
Melting point: mp 68-70.5°
Derivative Type: Nitrate
CAS Registry Number: 64872-77-1
Manufacturers' Codes: RS-35887
Trademarks: Femstat (Syntex); Gynomyk (Cassenne)
Molecular Formula: C19H17Cl3N2S.HNO3
Molecular Weight: 474.79
Percent Composition: C 48.06%, H 3.82%, Cl 22.40%, N 8.85%, S 6.75%, O 10.11%
Properties: Colorless blades from acetone/ethyl acetate, mp 162-163°. LD50 in mice, male, female rats (mg/kg): >3200, >3200, 1720 orally; >1600, 940, 940 i.p. (Walker).
Melting point: mp 162-163°
Toxicity data: LD50 in mice, male, female rats (mg/kg): >3200, >3200, 1720 orally; >1600, 940, 940 i.p. (Walker)
Therap-Cat: Antifungal (topical).
Keywords: Antifungal (Synthetic); Imidazoles.
Butoctamide Butofilolol Butopyronoxyl Butorphanol Butoxycaine

Systematic (IUPAC) name
Clinical data
Trade names Gynazole-1, Mycelex-3
AHFS/Drugs.com monograph
MedlinePlus a682012
Pregnancy cat. C (US)
Legal status OTC (US)
Routes Vaginal cream
CAS number 67085-13-6 YesY
ATC code G01AF15
PubChem CID 47472
DrugBank DB00639
ChemSpider 43192 YesY
UNII 0Q771797PH YesY
KEGG D00880 N
Chemical data
Formula C19H17Cl3N2S 
Mol. mass 411.776 g/mol
 N (what is this?)  (verify)

Butoconazole (trade names Gynazole-1, Mycelex-3) is an imidazole antifungal used in gynecology. It is administered as a vaginal cream.[1][2]