Cacodylic Acid

Title: Cacodylic Acid
CAS Registry Number: 75-60-5
CAS Name: Dimethylarsinic acid
Additional Names: hydroxydimethylarsine oxide
Trademarks: Phytar (Monterey)
Molecular Formula: C2H7AsO2
Molecular Weight: 138.00
Percent Composition: C 17.41%, H 5.11%, As 54.29%, O 23.19%
Line Formula: (CH3)2As(O)OH
Literature References: Prepn: Guinot, J. Pharm. Chim. 27, 55 (1923), C.A. 17, 21038 (1923); Inverni, Boll. Chim. Farm. 62, 129 (1923), C.A. 17, 24137 (1923); Challenger, Ellis, J. Chem. Soc. 1935, 396; Fioretti, Portelli, Ann. Chim. (Rome) 53, 1869 (1963), C.A. 60, 10712c (l964). Use as herbicide: Sprague, US 3056668 (1962 to Ansul). Toxicity study: G. W. Bailey, J. L. White, Residue Rev. 10, 97 (1965). Review of toxicology and human exposure: Toxicological Profile for Arsenic (PB2000-108021, 2000) 468 pp.
Properties: Crystals from alcohol + ether. mp 195-196°. Hygroscopic. Poisonous! Sol in 0.5 part water; very sol in alcohol; sol in acetic acid. Practically insol in ether. Keep well closed. LD50 orally in rats: 1350 mg/kg (Bailey, White).
Melting point: mp 195-196°
Toxicity data: LD50 orally in rats: 1350 mg/kg (Bailey, White)
Derivative Type: Mercury salt
Additional Names: Mercuric cacodylate
Molecular Formula: C4H12As2HgO4
Molecular Weight: 474.57
Percent Composition: C 10.12%, H 2.55%, As 31.57%, Hg 42.27%, O 13.49%
Properties: Hygroscopic, somewhat unstable cryst powder. Soluble in water, alcohol. Practically insol in ether. Keep well closed.
Use: Herbicide.
Therap-Cat: Dermatologic.
Therap-Cat-Vet: Has been used in chronic eczema, anemia and as a tonic.
Cacotheline Cactinomycin Cactus Grandiflorus Cadalene Cadaverine

Cacodylic acid
Structural formula
Ball-and-stick model
Identifiers
CAS number 75-60-5 YesY
PubChem 2513
ChemSpider 2418 YesY
UNII AJ2HL7EU8K YesY
EC number 200-883-4
DrugBank DB02994
KEGG C07308 YesY
ChEBI CHEBI:29839 N
RTECS number CH7525000
Jmol-3D images Image 1
Properties
Molecular formula C2H7AsO2
Molar mass 137.9977 g/mol
Appearance White crystals or powder
Density > 1.1 g/cm3
Melting point 192 - 198 °C
Boiling point > 200 °C
Solubility in water 667 g/l
Acidity (pKa) 6.3
Hazards
MSDS External MSDS
EU classification Very Toxic T+
R-phrases R26/27/28, R40
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Cacodylic acid is the chemical compound with the formula (CH3)2AsO2H. Derivatives of cacodylic acid, cacodylates, were frequently used as herbicides. For example, "Agent Blue," one of the chemicals used during the Vietnam War, is a mixture of cacodylic acid and sodium cacodylate. Sodium cacodylate is frequently used as a buffering agent in the preparation and fixation of biological samples for electron microscopy.