Calfactant

Title: Calfactant
CAS Registry Number: 183325-78-2
Additional Names: CLSE; CLL
Trademarks: Infasurf (Forest)
Literature References: Chloroform/methanol extract of calf lung lavage fluid. Consists of 35 mg/ml phospholipid, 55-70% of which is dipalmitoylphosphatidylcholine, and of low mol wt surfactant proteins. Also contains 0.9 mg/ml fatty acids and 1.8 mg/ml neutral lipids. See also: Beractant, Poractant Alfa. Prepn: R. H. Notter et al., Pediatr. Res. 16, 515 (1982). Physiologic effects in preterm lambs: J. J. Cummings et al., Am. Rev. Respir. Dis. 145, 999 (1992). Surface tension: E. M. Scarpelli et al., Am. J. Perinatol. 9, 414 (1992). Separation of hydrophobic constituents: S. B. Hall et al., J. Lipid Res. 35, 1386 (1994). Clinical trial in neonates: M. S. Kwong et al., Pediatrics 76, 585 (1985). Efficacy of prophylactic administration to neonates: J. Kattwinkel et al., ibid. 92, 90 (1993). Clinical trial in pediatric acute lung injury: D. F. Wilson et al., J. Am. Med. Assoc. 293, 470 (2005).
Therap-Cat: Pulmonary surfactant. In treatment of respiratory distress syndrome.
Keywords: Pulmonary Surfactant.
Calicheamicins Calixarenes Calmagite Calmodulin Calomelol

Calfactant
Clinical data
Trade names Infasurf
Pregnancy cat. N
Legal status -only (US)
Identifiers
ATC code None
UNII Q4K217VGA9 YesY
ChEMBL CHEMBL1201447 N
Chemical data
Formula  ?
 N (what is this?)  (verify)

Calfactant, also known as Infasurf,[1] is an intratracheal suspension derived from the natural surfactant in calf lungs. It is used in premature infants with lung surfactant deficiency that causes infant respiratory distress syndrome (IRDS).[2]